Oral Delivery of Anticancer Drugs II: the Prodrug Strategy

Overview

Journal Drug Discov Today

Specialty Pharmacology

Date 2012 Sep 11

PMID 22960308

Citations 7

Authors

Silvia Mazzaferro

Kawthar Bouchemal

Gilles Ponchel

Affiliations

Soon will be listed here.

Abstract

Many anticancer drugs are sparingly water soluble and they show a low permeability at the intestinal level. Furthermore, their oral bioavailability is impaired because they are substrates of the cytochrome P450 and of the efflux pumps. The prodrug strategy, which is discussed in the present review, represents one of the different approaches to overcome these obstacles. In this review, we highlight the progresses of clinical development in the prodrug area for the oral administration of anticancer drugs.

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