Ghrelin and Eating Disorders

Overview

Journal Prog Neuropsychopharmacol Biol Psychiatry

Specialty Psychiatry

Date 2012 Sep 11

PMID 22960103

Citations 19

Authors

Deniz Atalayer

Charlisa Gibson

Alexandra Konopacka

Allan Geliebter

Affiliations

Soon will be listed here.

Abstract

There is growing evidence supporting a multifactorial etiology that includes genetic, neurochemical, and physiological components for eating disorders above and beyond the more conventional theories based on psychological and sociocultural factors. Ghrelin is one of the key gut signals associated with appetite, and the only known circulating hormone that triggers a positive energy balance by stimulating food intake. This review summarizes recent findings and several conflicting reports on ghrelin in eating disorders. Understanding these findings and inconsistencies may help in developing new methods to prevent and treat patients with these disorders.

Citing Articles

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References

Whitson B, Leslie D, Kellogg T, Maddaus M, Buchwald H, Billington C . Entero-endocrine changes after gastric bypass in diabetic and nondiabetic patients: a preliminary study. J Surg Res. 2007; 141(1):31-9. DOI: 10.1016/j.jss.2007.02.022. View

Sullivan P . Mortality in anorexia nervosa. Am J Psychiatry. 1995; 152(7):1073-4. DOI: 10.1176/ajp.152.7.1073. View

Wren A, Seal L, Cohen M, Brynes A, Frost G, Murphy K . Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001; 86(12):5992. DOI: 10.1210/jcem.86.12.8111. View

Levin F, Edholm T, Ehrstrom M, Wallin B, Schmidt P, Kirchgessner A . Effect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat. Regul Pept. 2005; 131(1-3):59-65. DOI: 10.1016/j.regpep.2005.06.001. View

Kaye W, Wagner A, Fudge J, Paulus M . Neurocircuity of eating disorders. Curr Top Behav Neurosci. 2011; 6:37-57. PMC: 5957512. DOI: 10.1007/7854_2010_85. View

Abdu R, Garritano D, Culver O . Acute gastric necrosis in anorexia nervosa and bulimia. Two case reports. Arch Surg. 1987; 122(7):830-2. DOI: 10.1001/archsurg.1987.01400190096021. View

Janas-Kozik M, Krupka-Matuszczyk I, Malinowska-Kolodziej I, Lewin-Kowalik J . Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa. Regul Pept. 2006; 140(1-2):43-6. DOI: 10.1016/j.regpep.2006.11.005. View

Chen H, Trumbauer M, Chen A, Weingarth D, Adams J, Frazier E . Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology. 2004; 145(6):2607-12. DOI: 10.1210/en.2003-1596. View

Goto S, Nagao K, Bannai M, Takahashi M, Nakahara K, Kangawa K . Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment. Neuroscience. 2009; 166(1):333-40. DOI: 10.1016/j.neuroscience.2009.12.013. View

10.

Ando T, Ichimaru Y, Konjiki F, Shoji M, Komaki G . Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women. Am J Clin Nutr. 2007; 86(1):25-32. DOI: 10.1093/ajcn/86.1.25. View

11.

Monteleone P, Tortorella A, Castaldo E, Di Filippo C, Maj M . The Leu72Met polymorphism of the ghrelin gene is significantly associated with binge eating disorder. Psychiatr Genet. 2006; 17(1):13-6. DOI: 10.1097/YPG.0b013e328010e2c3. View

12.

Keel P, Holm-Denoma J, Crosby R . Clinical significance and distinctiveness of purging disorder and binge eating disorder. Int J Eat Disord. 2010; 44(4):311-6. PMC: 8674752. DOI: 10.1002/eat.20821. View

13.

Toshinai K, Yamaguchi H, Sun Y, Smith R, Yamanaka A, Sakurai T . Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology. 2006; 147(5):2306-14. DOI: 10.1210/en.2005-1357. View

14.

Pemberton C, Richards A . Biochemistry of ghrelin precursor peptides. Vitam Horm. 2007; 77:13-30. DOI: 10.1016/S0083-6729(06)77002-9. View

15.

Tanaka M, Naruo T, Muranaga T, Yasuhara D, Shiiya T, Nakazato M . Increased fasting plasma ghrelin levels in patients with bulimia nervosa. Eur J Endocrinol. 2002; 146(6):R1-3. DOI: 10.1530/eje.0.146r001. View

16.

Nagaya N, Uematsu M, Kojima M, Ikeda Y, Yoshihara F, Shimizu W . Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation. 2001; 104(12):1430-5. DOI: 10.1161/hc3601.095575. View

17.

Jerlhag E, Egecioglu E, Dickson S, Douhan A, Svensson L, Engel J . Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addict Biol. 2007; 12(1):6-16. DOI: 10.1111/j.1369-1600.2006.00041.x. View

18.

Carlini V, Monzon M, Varas M, Cragnolini A, Schioth H, Scimonelli T . Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem Biophys Res Commun. 2002; 299(5):739-43. DOI: 10.1016/s0006-291x(02)02740-7. View

19.

Soriano-Guillen L, Barrios V, Campos-Barros A, Argente J . Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation. J Pediatr. 2004; 144(1):36-42. DOI: 10.1016/j.jpeds.2003.10.036. View

20.

Rowland N, Morien A, Li B . The physiology and brain mechanisms of feeding. Nutrition. 1996; 12(9):626-39. DOI: 10.1016/s0899-9007(96)00227-4. View