Temporal Lobe Epilepsy in Children

Overview

Journal Epilepsy Res Treat

Date 2012 Sep 8

PMID 22957247

Citations 10

Authors

Katherine C Nickels

Lily C Wong-Kisiel

Brian D Moseley

Elaine C Wirrell

Affiliations

Soon will be listed here.

Abstract

The temporal lobe is a common focus for epilepsy. Temporal lobe epilepsy in infants and children differs from the relatively homogeneous syndrome seen in adults in several important clinical and pathological ways. Seizure semiology varies by age, and the ictal EEG pattern may be less clear cut than what is seen in adults. Additionally, the occurrence of intractable seizures in the developing brain may impact neurocognitive function remote from the temporal area. While many children will respond favorably to medical therapy, those with focal imaging abnormalities including cortical dysplasia, hippocampal sclerosis, or low-grade tumors are likely to be intractable. Expedient workup and surgical intervention in these medically intractable cases are needed to maximize long-term developmental outcome.

Citing Articles

Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review.

Cappelletto P, Accolla C, Preti M, Pisano T, Barba C, Guerrini R Epilepsia Open. 2024; 10(1):74-84.

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Low-grade glioma of the temporal lobe and tumor-related epilepsy in children.

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MicroRNAs as potential biomarkers in temporal lobe epilepsy and mesial temporal lobe epilepsy.

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Chronic pediatric diseases and risk for reading difficulties: a narrative review with recommendations.

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Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review.

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References

Lee Y, Kang H, Bae S, Kim H, Kim J, Lee B . Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy. Childs Nerv Syst. 2009; 26(2):177-83. DOI: 10.1007/s00381-009-1015-3. View

Doose H, Sitepu B . Childhood epilepsy in a German city. Neuropediatrics. 1983; 14(4):220-4. DOI: 10.1055/s-2008-1059582. View

Adelow C, Andell E, Amark P, Andersson T, Hellebro E, Ahlbom A . Newly diagnosed single unprovoked seizures and epilepsy in Stockholm, Sweden: First report from the Stockholm Incidence Registry of Epilepsy (SIRE). Epilepsia. 2008; 50(5):1094-101. DOI: 10.1111/j.1528-1167.2008.01726.x. View

Feichtinger M, Pauli E, Schafer I, Eberhardt K, Tomandl B, Huk J . Ictal fear in temporal lobe epilepsy: surgical outcome and focal hippocampal changes revealed by proton magnetic resonance spectroscopy imaging. Arch Neurol. 2001; 58(5):771-7. DOI: 10.1001/archneur.58.5.771. View

Moddel G, Lineweaver T, Schuele S, Reinholz J, Loddenkemper T . Atypical language lateralization in epilepsy patients. Epilepsia. 2009; 50(6):1505-16. DOI: 10.1111/j.1528-1167.2008.02000.x. View

Crompton D, Scheffer I, Taylor I, Cook M, McKelvie P, Vears D . Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance. Brain. 2010; 133(11):3221-31. DOI: 10.1093/brain/awq251. View

Lendt M, Helmstaedter C, Kuczaty S, Schramm J, Elger C . Behavioural disorders in children with epilepsy: early improvement after surgery. J Neurol Neurosurg Psychiatry. 2000; 69(6):739-44. PMC: 1737160. DOI: 10.1136/jnnp.69.6.739. View

Davies S, Heyman I, Goodman R . A population survey of mental health problems in children with epilepsy. Dev Med Child Neurol. 2003; 45(5):292-5. DOI: 10.1017/s0012162203000550. View

Cavalheiro E, Silva D, Turski W, Bortolotto Z, Turski L . The susceptibility of rats to pilocarpine-induced seizures is age-dependent. Brain Res. 1987; 465(1-2):43-58. DOI: 10.1016/0165-3806(87)90227-6. View

10.

Kakisaka Y, Haginoya K, Ishitobi M, Togashi N, Kitamura T, Wakusawa K . Utility of subtraction ictal SPECT images in detecting focal leading activity and understanding the pathophysiology of spasms in patients with West syndrome. Epilepsy Res. 2008; 83(2-3):177-83. DOI: 10.1016/j.eplepsyres.2008.11.005. View

11.

Westmoreland B . The electroencephalogram in patients with epilepsy. Neurol Clin. 1985; 3(3):599-613. View

12.

Mohamed A, Wyllie E, Ruggieri P, Kotagal P, Babb T, Hilbig A . Temporal lobe epilepsy due to hippocampal sclerosis in pediatric candidates for epilepsy surgery. Neurology. 2001; 56(12):1643-9. DOI: 10.1212/wnl.56.12.1643. View

13.

Ramos E, Benbadis S, Vale F . Failure of temporal lobe resection for epilepsy in patients with mesial temporal sclerosis: results and treatment options. J Neurosurg. 2009; 110(6):1127-34. DOI: 10.3171/2009.1.JNS08638. View

14.

Mizrahi E, KELLAWAY P, Grossman R, Rutecki P, Armstrong D, Rettig G . Anterior temporal lobectomy and medically refractory temporal lobe epilepsy of childhood. Epilepsia. 1990; 31(3):302-12. DOI: 10.1111/j.1528-1157.1990.tb05380.x. View

15.

Bisulli F, Tinuper P, Avoni P, Striano P, Striano S, dOrsi G . Idiopathic partial epilepsy with auditory features (IPEAF): a clinical and genetic study of 53 sporadic cases. Brain. 2004; 127(Pt 6):1343-52. DOI: 10.1093/brain/awh151. View

16.

Christensen J, Vestergaard M, Pedersen M, Pedersen C, Olsen J, Sidenius P . Incidence and prevalence of epilepsy in Denmark. Epilepsy Res. 2007; 76(1):60-5. DOI: 10.1016/j.eplepsyres.2007.06.012. View

17.

OBrien T, So E, Mullan B, Hauser M, Brinkmann B, Jack Jr C . Subtraction SPECT co-registered to MRI improves postictal SPECT localization of seizure foci. Neurology. 1999; 52(1):137-46. DOI: 10.1212/wnl.52.1.137. View

18.

Ray A, Kotagal P . Temporal lobe epilepsy in children: overview of clinical semiology. Epileptic Disord. 2005; 7(4):299-307. View

19.

Shih J, Weisend M, Sanders J, Lee R . Magnetoencephalographic and magnetic resonance spectroscopy evidence of regional functional abnormality in mesial temporal lobe epilepsy. Brain Topogr. 2010; 23(4):368-74. DOI: 10.1007/s10548-010-0156-8. View

20.

Bartolomei F, Hayashi M, Tamura M, Rey M, Fischer C, Chauvel P . Long-term efficacy of gamma knife radiosurgery in mesial temporal lobe epilepsy. Neurology. 2008; 70(19):1658-63. DOI: 10.1212/01.wnl.0000294326.05118.d8. View