Total Saponin from Root of Actinidia Valvata Dunn Inhibits Hepatoma 22 Growth and Metastasis In Vivo by Suppression Angiogenesis

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2012 Sep 8

PMID 22956974

Citations 3

Authors

Guo-Yin Zheng

Hai-Liang Xin

Yan-Fen Xu

Bai Li

Xiao-Feng Zhai

Yuan-Hui Zhang

Chang-Quan Ling

Affiliations

Soon will be listed here.

Abstract

The root of Actinidia valvata dunn has been widely used in the treatment of hepatocellular carcinoma (HCC), proved to be beneficial for a longer and better life in China. In present work, total saponin from root of Actinidia valvata Dunn (TSAVD) was extracted, and its effects on hepatoma H22-based mouse in vivo were observed. Primarily transplanted hypodermal hepatoma H22-based mice were used to observe TSAVD effect on tumor growth. The microvessel density (MVD), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) are characterized factors of angiogenesis, which were compared between TSAVD-treated and control groups. Antimetastasis effect on experimental pulmonary metastasis hepatoma mice was also observed in the study. The results demonstrated that TSAVD can effectively inhibit HCC growth and metastasis in vivo, inhibit the formation of microvessel, downregulate expressions of VEGF and bFGF, and retrain angiogenesis of hepatoma 22 which could be one of the reasons.

Citing Articles

Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways.

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The Chinese medicine Sini-San inhibits HBx-induced migration and invasiveness of human hepatocellular carcinoma cells.

Lin H, Kao S, Siao Y, Yeh C BMC Complement Altern Med. 2015; 15:348.

PMID: 26446078 PMC: 4597375. DOI: 10.1186/s12906-015-0870-6.

Hepatoprotective Activity of the Total Saponins from Actinidia valvata Dunn Root against Carbon Tetrachloride-Induced Liver Damage in Mice.

Qu L, Xin H, Zheng G, Su Y, Ling C Evid Based Complement Alternat Med. 2012; 2012:216061.

PMID: 23243434 PMC: 3518303. DOI: 10.1155/2012/216061.

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