Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction Via Beta Cell ABCA1

Overview

Journal Diabetes Metab J

Specialty Endocrinology

Date 2012 Sep 6

PMID 22950058

Citations 3

Authors

Hannah Seok

Ji Young Lee

Eun Mi Park

Se Eun Park

Jae Hyuk Lee

Seungtaek Lim

Byung-Wan Lee

Eun Seok Kang

Hyun Chul Lee

Bong Soo Cha

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction.

Methods: In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a high-fat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter.

Results: In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased β-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels.

Conclusion: These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of β-cell function via increasing β-cell ABCA1 expression.

Citing Articles

The Effect of Balsamic Vinegar Dressing on Protein and Carbohydrate Digestibility is Dependent on the Food Matrix.

Urbinati E, Di Nunzio M, Picone G, Chiarello E, Bordoni A, Capozzi F Foods. 2021; 10(2).

PMID: 33673211 PMC: 7917894. DOI: 10.3390/foods10020411.

Safety and side effects of apple vinegar intake and its effect on metabolic parameters and body weight: a systematic review.

Launholt T, Kristiansen C, Hjorth P Eur J Nutr. 2020; 59(6):2273-2289.

PMID: 32170375 DOI: 10.1007/s00394-020-02214-3.

Nypa fruticans Wurmb. Vinegar's Aqueous Extract Stimulates Insulin Secretion and Exerts Hepatoprotective Effect on STZ-Induced Diabetic Rats.

Yusoff N, Lim V, Al-Hindi B, Abdul Razak K, Widyawati T, Anggraini D Nutrients. 2017; 9(9).

PMID: 28832548 PMC: 5622685. DOI: 10.3390/nu9090925.

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