Detection of Ocular Toxoplasma Gondii Infection in Chronic Irregular Recurrent Uveitis by PCR

Overview

Journal Korean J Parasitol

Specialty Parasitology

Date 2012 Sep 6

PMID 22949751

Citations 5

Authors

Sang-Eun Lee

Sung-Hee Hong

Seong-Ho Lee

Young-Il Jeong

Su Jin Lim

Oh Woong Kwon

Sun Hyun Kim

Young Sung You

Shin-Hyeong Cho

Won-Ja Lee

Affiliations

Soon will be listed here.

Abstract

Toxoplasma gondii is a zoonotic parasite resulting in human infections and one of the infectious pathogens leading to uveitis and retinochoroiditis. The present study was performed to assess T. gondii infection in 20 ocular patients with chronic irregular recurrent uveitis (20 aqueous humor and 20 peripheral blood samples) using PCR. All samples were analyzed by nested PCR targeting a specific B1 gene of T. gondii. The PCR-positive rate was 25% (5/20), including 5% (1) in blood samples, 25% (5) in aqueous humor samples, and 5% (1) in both sample types. A molecular screening test for T. gondii infection in ocular patients with common clinical findings of an unclear retinal margin and an inflammatory membrane over the retina, as seen by fundus examination, may be helpful for early diagnosis and treatment.

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