Whole-body Vibration Decreases the Proliferativeb Response of TCD4(+) Cells in Elderly Individuals with Knee Osteoarthritis
Overview
General Medicine
Authors
Affiliations
The aim of this study was to investigate the effect of adding whole-body vibration (WBV; frequency = 35 to 40 Hz; amplitude = 4 mm) to squat training on the T-cell proliferative response of elderly patients with osteoarthritis (OA) of the knee. This study was a randomized controlled trial in which the selected variables were assessed before and after 12 weeks of training. Twenty-six subjects (72 ± 5 years of age) were divided into three groups: 1) squat training with WBV (WBV, N = 8); 2) squat training without WBV (N = 10), and 3) a control group (N = 8). Women who were ≥60 years of age and had been diagnosed with OA in at least one knee were eligible. The intervention consisted of 12 uninterrupted weeks of squatting exercise training performed 3 times/week. Peripheral blood mononuclear cells were obtained from peripheral blood collected before and after training. The proliferation of TCD4+ and TCD8+ cells was evaluated by flow cytometry measuring the carboxyfluorescein succinimidyl ester fluorescence decay before and after the intervention (∆). The proliferative response of TCD4+ cells (P = 0.02, effect size = 1.0) showed a significant decrease (23%) in the WBV group compared to the control group, while there was no difference between groups regarding the proliferative response of TCD8+ cells (P = 0.12, effect size = 2.23). The data suggest that the addition of WBV to squat exercise training might modulate T-cell-mediated immunity, minimizing or slowing disease progression in elderly patients with OA of the knee.
Ahuja G, Arenales Arauz Y, van Heuvelen M, Kortholt A, Oroszi T, van der Zee E Front Neurol. 2024; 15:1422152.
PMID: 39144715 PMC: 11323691. DOI: 10.3389/fneur.2024.1422152.
Blanks A, Rodriguez-Miguelez P, Looney J, Tucker M, Jeong J, Thomas J Brain Behav Immun Health. 2024; 1:100011.
PMID: 38377415 PMC: 8474538. DOI: 10.1016/j.bbih.2019.100011.
Sanudo B, Seixas A, Gloeckl R, Rittweger J, Rawer R, Taiar R Int J Environ Res Public Health. 2020; 17(10).
PMID: 32455961 PMC: 7277771. DOI: 10.3390/ijerph17103650.
Costa L, Ottoni M, Santos M, Meireles A, Almeida V, Pereira W Molecules. 2017; 22(11).
PMID: 29125561 PMC: 6150313. DOI: 10.3390/molecules22111789.
EFFECT OF A SHORT PERIOD WHOLE BODY VIBRATION WITH 10 HZ ON BLOOD BIOMARKERS IN RATS.
Monteiro M, da Cunha de Sa-Caputo D, Moreira-Marconi E, Frederico E, de Sousa-Goncalves C, Bernardo L Afr J Tradit Complement Altern Med. 2017; 14(4 Suppl):11-18.
PMID: 28740939 PMC: 5514436. DOI: 10.21010/ajtcam.v14i4S.2.