Alpha-globin Gene Markers Identify Genetic Differences Between Australian Aborigines and Melanesians

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1990 Jan 1

PMID 2294746

Citations 9

Authors

A S Tsintsof

M S Hertzberg

J F Prior

K N Mickleson

R J Trent

Affiliations

Soon will be listed here.

Abstract

Australian aborigines exhibit a number of alpha-globin cluster rearrangements involving both alpha- and zeta-globin genes. alpha+-Thalassemia (-alpha/) in this population is heterogeneous and includes the 3.7 types I, II, and III gene deletions. The alpha alpha alpha/ and zeta zeta zeta/ rearrangements are each found in association with two haplotypes, indicating origins from at least two separate DNA crossover events. Differences in alpha-globin cluster rearrangements and in haplotypes between Australian aborigines, Papua New Guinea highlanders and island Melanesians, are consistent with multiple colonizing events into Australia.

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