Passive Immunization Prevents Induction of Lyme Arthritis in LSH Hamsters

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1990 Jan 1

PMID 2294046

Citations 27

Authors

J L Schmitz

R F Schell

A G Hejka

D M England

Affiliations

Soon will be listed here.

Abstract

We determined that sera obtained from hamsters infected with Borrelia burgdorferi could prevent the induction of Lyme arthritis. When irradiated hamsters were administered immune serum and subsequently challenged with B. burgdorferi, no evidence of infection was detected. Recipients failed to develop swelling of the hind paws, and no histopathologic changes were detected. In addition, B. burgdorferi was not recovered from tissues of hamsters that were passively immunized. By contrast, irradiated hamsters that were administered normal hamster serum or saline and infected with the Lyme spirochete developed arthritis. Extensive histopathologic changes occurred in the hind paws and knee joints, and spirochetes were recovered from most of the tissues examined. These results show that immune serum can confer complete protection on recipient hamsters to challenge with B. burgdorferi.

Citing Articles

Stability of erp loci during Borrelia burgdorferi infection: recombination is not required for chronic infection of immunocompetent mice.

El Hage N, Lieto L, Stevenson B Infect Immun. 1999; 67(6):3146-50.

PMID: 10338534 PMC: 96635. DOI: 10.1128/IAI.67.6.3146-3150.1999.

Macrophages and enriched populations of T lymphocytes interact synergistically for the induction of severe, destructive Lyme arthritis.

DuChateau B, Jensen J, England D, Callister S, Lovrich S, Schell R Infect Immun. 1997; 65(7):2829-36.

PMID: 9199456 PMC: 175398. DOI: 10.1128/iai.65.7.2829-2836.1997.

Macrophages exposed to Borrelia burgdorferi induce Lyme arthritis in hamsters.

Du Chateau B, England D, Callister S, Lim L, Lovrich S, Schell R Infect Immun. 1996; 64(7):2540-7.

PMID: 8698477 PMC: 174108. DOI: 10.1128/iai.64.7.2540-2547.1996.

Passive immunizing activity of sera from mice infected with Borrelia burgdorferi.

Barthold S, Bockenstedt L Infect Immun. 1993; 61(11):4696-702.

PMID: 8406868 PMC: 281223. DOI: 10.1128/iai.61.11.4696-4702.1993.

Seroprotective groups among isolates of Borrelia burgdorferi.

Lovrich S, Callister S, Lim L, Schell R Infect Immun. 1993; 61(10):4367-74.

PMID: 8406827 PMC: 281168. DOI: 10.1128/iai.61.10.4367-4374.1993.

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