Adenosine and Autism: a Spectrum of Opportunities

Overview

Journal Neuropharmacology

Specialties Neurology
Pharmacology

Date 2012 Sep 4

PMID 22940000

Citations 20

Authors

Susan A Masino

Masahito Kawamura Jr

Jessica L Cote

Rebecca B Williams

David N Ruskin

Affiliations

Soon will be listed here.

Abstract

In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system activity, increasing adenosine's influence might be a new therapeutic target for autism with multiple beneficial effects. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'.

Citing Articles

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Concurrent Assessment of Oxidative Stress and MT-ATP6 Gene Profiling to Facilitate Diagnosis of Autism Spectrum Disorder (ASD) in Tamil Nadu Population.

Vellingiri B, Venkatesan D, Iyer M, Mohan G, Krishnan P, Krishna K J Mol Neurosci. 2023; 73(4-5):214-224.

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Epilepsy and Autism Spectrum Disorder (ASD): The Underlying Mechanisms and Therapy Targets Related to Adenosine.

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Murugan M, Fedele D, Millner D, Alharfoush E, Vegunta G, Boison D Neurochem Int. 2021; 147:105054.

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Developmental Role of Adenosine Kinase in the Cerebellum.

Gebril H, Wahba A, Zhou X, Lai T, Alharfoush E, DiCicco-Bloom E eNeuro. 2021; 8(3).

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References

RYLANDER G . Psychoses and the punding and choreiform syndromes in addiction to central stimulant drugs. Psychiatr Neurol Neurochir. 1972; 75(3):203-12. View

Masino S, Li T, Theofilas P, Sandau U, Ruskin D, Fredholm B . A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. J Clin Invest. 2011; 121(7):2679-83. PMC: 3223846. DOI: 10.1172/JCI57813. View

Kawamura Jr M, Ruskin D, Masino S . Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors, and KATP channels. J Neurosci. 2010; 30(11):3886-95. PMC: 2872120. DOI: 10.1523/JNEUROSCI.0055-10.2010. View

Johansson B, Halldner L, Dunwiddie T, Masino S, Poelchen W, Gimenez-Llort L . Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A. 2001; 98(16):9407-12. PMC: 55434. DOI: 10.1073/pnas.161292398. View

Wheless J . History of the ketogenic diet. Epilepsia. 2008; 49 Suppl 8:3-5. DOI: 10.1111/j.1528-1167.2008.01821.x. View

Leekam S, Nieto C, Libby S, Wing L, Gould J . Describing the sensory abnormalities of children and adults with autism. J Autism Dev Disord. 2006; 37(5):894-910. DOI: 10.1007/s10803-006-0218-7. View

Ribeiro J, Sebastiao A . Caffeine and adenosine. J Alzheimers Dis. 2010; 20 Suppl 1:S3-15. DOI: 10.3233/JAD-2010-1379. View

Masino S, Kawamura Jr M, Plotkin L, Svedova J, DiMario Jr F, Eigsti I . The relationship between the neuromodulator adenosine and behavioral symptoms of autism. Neurosci Lett. 2011; 500(1):1-5. PMC: 3745825. DOI: 10.1016/j.neulet.2011.06.007. View

Masino S, Kawamura M, Wasser C, Wasser C, Pomeroy L, Ruskin D . Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Curr Neuropharmacol. 2010; 7(3):257-68. PMC: 2769009. DOI: 10.2174/157015909789152164. View

10.

Hassan A, Keene D, Whiting S, Jacob P, Champagne J, Humphreys P . Ketogenic diet in the treatment of refractory epilepsy in childhood. Pediatr Neurol. 1999; 21(2):548-52. DOI: 10.1016/s0887-8994(99)00045-4. View

11.

Haas R, Rice M, Trauner D, Merritt T . Therapeutic effects of a ketogenic diet in Rett syndrome. Am J Med Genet Suppl. 1986; 1:225-46. DOI: 10.1002/ajmg.1320250525. View

12.

Rudolphi K, Keil M, Fastbom J, Fredholm B . Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment. Neurosci Lett. 1989; 103(3):275-80. DOI: 10.1016/0304-3940(89)90112-2. View

13.

Grandin T . Visual abilities and sensory differences in a person with autism. Biol Psychiatry. 2008; 65(1):15-6. DOI: 10.1016/j.biopsych.2008.11.005. View

14.

Ilie A, Raimondo J, Akerman C . Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. J Neurosci. 2012; 32(15):5321-32. PMC: 6622092. DOI: 10.1523/JNEUROSCI.5412-11.2012. View

15.

Tuchman R, Rapin I . Epilepsy in autism. Lancet Neurol. 2003; 1(6):352-8. DOI: 10.1016/s1474-4422(02)00160-6. View

16.

Bartz J, Hollander E . Oxytocin and experimental therapeutics in autism spectrum disorders. Prog Brain Res. 2008; 170:451-62. DOI: 10.1016/S0079-6123(08)00435-4. View

17.

Satoh S, Matsumura H, HAYAISHI O . Involvement of adenosine A2A receptor in sleep promotion. Eur J Pharmacol. 1998; 351(2):155-62. DOI: 10.1016/s0014-2999(98)00302-1. View

18.

Fredholm B, BATTIG K, Holmen J, Nehlig A, Zvartau E . Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999; 51(1):83-133. View

19.

Schmidt A, Bohmer A, Antunes C, Schallenberger C, Porciuncula L, Elisabetsky E . Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009; 156(1):163-72. PMC: 2697763. DOI: 10.1111/j.1476-5381.2008.00025.x. View

20.

Poleszak E, MALEC D . Influence of adenosine receptor agonists and antagonists on amphetamine-induced stereotypy in rats. Pol J Pharmacol. 2001; 52(6):423-9. View