Addition of Aripiprazole to the Clozapine May Be Useful in Reducing Anxiety in Treatment-resistant Schizophrenia

Overview

Journal Case Rep Psychiatry

Publisher Wiley

Specialty Psychiatry

Date 2012 Sep 1

PMID 22937411

Citations 2

Authors

Aleksandar Chanachev

Nicolas Ansermot

Severine Crettol Wavre

Ute Nowotka

Maria-Eleni Stamatopoulou

Philippe Conus

Chin B Eap

Affiliations

Soon will be listed here.

Abstract

There exist many case reports and studies on the antipsychotic augmentation by aripirazole in partial responders to clozapine, the most seem to be finding a slight difference in the PANSS and CGI scores after the aripirazole addition. The results of our report are compatible with those of other studies but, we have found a considerable antianxiety action in both of the cases. The 5HT1A agonism of aripirazole could be hypothesized as mechanism contributing to this effect.

Citing Articles

A Comparative Study of Short Term Efficacy of Aripiprazole and Risperidone in Schizophrenia.

Kumar P B S, Pandey R, Thirthalli J, Kumar P T S, Kumar C N Curr Neuropharmacol. 2017; 15(8):1073-1084.

PMID: 28088913 PMC: 5725539. DOI: 10.2174/1570159X15666170113100611.

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia.

Eryilmaz G, Sayar G, Ozten E, Gogcegoz Gul I, Karamustafalioglu O Ann Gen Psychiatry. 2013; 12(1):40.

PMID: 24330737 PMC: 3874630. DOI: 10.1186/1744-859X-12-40.

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