Emerging Roles of Alternative Pre-mRNA Splicing Regulation in Neuronal Development and Function

Overview

Journal Front Neurosci

Date 2012 Sep 1

PMID 22936897

Citations 47

Authors

Adam D Norris

John A Calarco

Affiliations

Soon will be listed here.

Abstract

Alternative pre-mRNA splicing has the potential to greatly diversify the repertoire of transcripts in multicellular organisms. Increasing evidence suggests that this expansive layer of gene regulation plays a particularly important role in the development and function of the nervous system, one of the most complex organ systems found in nature. In this review, we highlight recent studies that continue to emphasize the influence and contribution of alternative splicing regulation to various aspects of neuronal development in addition to its role in the mature nervous system.

Citing Articles

Splicing to orchestrate cell fate.

Zhang X, Guo Z, Li Y, Xu Y Mol Ther Nucleic Acids. 2025; 36(1):102416.

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Deep Transcriptomics Reveals Cell-Specific Isoforms of Pan-Neuronal Genes.

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Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain.

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Muscleblind-1 interacts with tubulin mRNAs to regulate the microtubule cytoskeleton in C. elegans mechanosensory neurons.

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