Asymmetric Michael Additions of α-nitrocyclohexanone to Aryl Nitroalkenes Catalyzed by Natural Amino Acid-derived Bifunctional Thioureas
Overview
Chemistry
Affiliations
A series of new thiourea catalysts prepared from natural amino acids have been applied in organocatalytic asymmetric Michael additions of α-nitrocyclohexanone to nitroalkenes. The resulting addition products are formed with excellent enantioselectivities (up to an er of 98:2) in good yields (up to 90%).
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