Aspirin Sensitivity and Chronic Rhinosinusitis with Polyps: a Fatal Combination

Overview

Journal J Allergy (Cairo)

Specialty Allergy & Immunology

Date 2012 Aug 29

PMID 22927869

Citations 10

Authors

Hendrik Graefe

Christina Roebke

Dirk Schafer

Jens Eduard Meyer

Affiliations

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Abstract

Aspirin-exacerbated respiratory disease (AERD) refers to aspirin sensitivity, chronic rhinosinusitis (CRS), nasal polyposis, asthma, eosinophil inflammation in the upper and lower airways, urticaria, angioedema, and anaphylaxis following the ingestion of NSAIDs. Epidemiologic and pathophysiological links between these diseases are established. The precise pathogenesis remains less defined, even though there is some progress in the understanding of several molecular mechanisms. Nevertheless, these combinations of diseases in patients classified by AERD constitute a fatal combination and may be difficult to treat with standard medical and surgical interventions. This paper reviews in brief the epidemiology, clinical features, diagnosis, molecular pathogenesis, and specific therapies of patients classified by AERD and postulates future attempts to gain new insights into this disease.

Citing Articles

Epidemiology, Sociodemographic Factors and Comorbidity for Allergic Rhinitis, Asthma, and Rhinosinusitis Among 15 to 65-year-Old Iranian Patients.

Nabavizadeh S, Moghtaderi M, Alyasin S, Esmaeilzadeh H, Teshnizi S, Jabbari-Azad F Med J Islam Repub Iran. 2023; 36:128.

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Presence of positive skin prick tests to inhalant allergens and markers of T2 inflammation in subjects with chronic spontaneous urticaria (CSU): a systematic literature review.

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Kounis syndrome induced by oral intake of aspirin: case report and literature review.

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Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study.

Philpott C, Sunkaraneni S, Wilson A, Erskine S, Philpott C, Clark A Respir Res. 2018; 19(1):129.

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Aspirin-exacerbated respiratory disease and current treatment modalities.

Sakalar E, Bayar Muluk N, Kar M, Cingi C Eur Arch Otorhinolaryngol. 2016; 274(3):1291-1300.

PMID: 27538737 DOI: 10.1007/s00405-016-4273-1.

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