Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia Japonica)

Overview

Journal Adv Pharmacol Sci

Date 2012 Aug 29

PMID 22927840

Citations 26

Authors

Takuhiro Uto

De-Xing Hou

Osamu Morinaga

Yukihiro Shoyama

Affiliations

Soon will be listed here.

Abstract

6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major bioactive compound in wasabi (Wasabia japonica), which is a typical Japanese pungent spice. Recently, in vivo and in vitro studies demonstrated that 6-MSITC has several biological properties, including anti-inflammatory, antimicrobial, antiplatelet, and anticancer effects. We previously reported that 6-MSITC strongly suppresses cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cytokines, which are important factors that mediate inflammatory processes. Moreover, molecular analysis demonstrated that 6-MSITC blocks the expressions of these factors by suppressing multiple signal transduction pathways to attenuate the activation of transcriptional factors. Structure-activity relationships of 6-MSITC and its analogues containing an isothiocyanate group revealed that methylsulfinyl group and the length of alkyl chain of 6-MSITC might be related to high inhibitory potency. In this paper, we review the anti-inflammatory properties of 6-MSITC and discuss potential molecular mechanisms focusing on inflammatory responses by macrophages.

Citing Articles

Immunomodulatory Effects and Regulatory Mechanisms of ()-6-HITC, an Isothiocyanate from Wasabi (), in an Mouse Model of LPS-Induced Inflammation.

Alcarranza M, Alarcon-de-la-Lastra C, Recio Jimenez R, Fernandez I, Castejon Martinez M, Villegas I J Agric Food Chem. 2024; 72(39):21520-21532.

PMID: 39298284 PMC: 11450934. DOI: 10.1021/acs.jafc.4c02943.

Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer's Disease, and Obesity.

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Allyl isothiocyanate and 6-(methylsulfinyl) hexyl isothiocyanate contents vary among wild and cultivated wasabi ().

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Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers.

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