The Use of Salivary Cytokines As a Screening Tool for Oral Squamous Cell Carcinoma : A Review of the Literature

Overview

Journal J Oral Maxillofac Pathol

Date 2012 Aug 28

PMID 22923900

Citations 13

Authors

Tarig A Osman

Daniela E Costea

Anne C Johannessen

Affiliations

Soon will be listed here.

Abstract

Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer. The 5-year survival rate has remained below 50% over the last two decades, and new tools for early diagnosis are needed. Saliva has been used for diagnosis of several systemic diseases, and its use for diagnosis of OSCC has been sought extensively. Among the many salivary analytes for diagnosis of OSCC, accumulating evidences indicate the possibility of using salivary cytokines. Overproduction of proinflammatory, proangiogenic cytokines by OSCC cells has been reported, and their role in tumor progression and angiogenesis is well established. However, many inflammatory conditions and immunological diseases could affect the levels of cytokines in serum and saliva. This article has reviewed publications in this matter, and some strengths and weaknesses have been pointed out. Conclusively, large-scale investigations are required for validation of the use of salivary cytokines for diagnosis of OSCC, with consideration to the influential role of periodontal inflammation in their levels.

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References

Allison P, Locker D, Feine J . The role of diagnostic delays in the prognosis of oral cancer: a review of the literature. Oral Oncol. 1998; 34(3):161-70. DOI: 10.1016/s1368-8375(97)00071-7. View

Kinney J, Ramseier C, Giannobile W . Oral fluid-based biomarkers of alveolar bone loss in periodontitis. Ann N Y Acad Sci. 2007; 1098:230-51. PMC: 2570328. DOI: 10.1196/annals.1384.028. View

Jablonska E, Piotrowski L, Grabowska Z . Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer. Pathol Oncol Res. 1997; 3(2):126-129. DOI: 10.1007/BF02907807. View

Streckfus C, Bigler L, Dellinger T, Dai X, Kingman A, Thigpen J . The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study. Clin Cancer Res. 2000; 6(6):2363-70. View

Marchetti P, Benzi L, Masoni A, Cecchetti P, Giannarelli R, Di Cianni G . Salivary insulin concentrations in type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects: relationship to changes in plasma insulin levels after an oral glucose load. Diabetologia. 1986; 29(10):695-8. DOI: 10.1007/BF00870278. View

Wu J, Yi C, Chung H, Wang D, Chang W, Lee S . Potential biomarkers in saliva for oral squamous cell carcinoma. Oral Oncol. 2010; 46(4):226-31. DOI: 10.1016/j.oraloncology.2010.01.007. View

MASHBERG A, Samit A . Early diagnosis of asymptomatic oral and oropharyngeal squamous cancers. CA Cancer J Clin. 1995; 45(6):328-51. DOI: 10.3322/canjclin.45.6.328. View

Juusola J, Ballantyne J . Messenger RNA profiling: a prototype method to supplant conventional methods for body fluid identification. Forensic Sci Int. 2003; 135(2):85-96. DOI: 10.1016/s0379-0738(03)00197-x. View

Bigler L, Streckfus C, Copeland L, Burns R, Dai X, Kuhn M . The potential use of saliva to detect recurrence of disease in women with breast carcinoma. J Oral Pathol Med. 2002; 31(7):421-31. DOI: 10.1034/j.1600-0714.2002.00123.x. View

10.

Sato J, Goto J, Murata T, Kitamori S, Yamazaki Y, Satoh A . Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110(3):330-6. DOI: 10.1016/j.tripleo.2010.03.040. View

11.

Funk G, Karnell L, Robinson R, Zhen W, Trask D, Hoffman H . Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. Head Neck. 2002; 24(2):165-80. DOI: 10.1002/hed.10004. View

12.

Vokes E, Weichselbaum R, Lippman S, Hong W . Head and neck cancer. N Engl J Med. 1993; 328(3):184-94. DOI: 10.1056/NEJM199301213280306. View

13.

Choo R, Huestis M . Oral fluid as a diagnostic tool. Clin Chem Lab Med. 2004; 42(11):1273-87. DOI: 10.1515/CCLM.2004.248. View

14.

Franzmann E, Reategui E, Pedroso F, Pernas F, Karakullukcu B, Carraway K . Soluble CD44 is a potential marker for the early detection of head and neck cancer. Cancer Epidemiol Biomarkers Prev. 2007; 16(7):1348-55. DOI: 10.1158/1055-9965.EPI-06-0011. View

15.

Feng X, Li J, Li J, Han Z, Xing R . Serum SCCA, Cyfra 21-1, EGFR and Cyclin D1 levels in patients with oral squamous cell carcinoma. Int J Biol Markers. 2010; 25(2):93-8. DOI: 10.1177/172460081002500206. View

16.

Haas C, Klesser B, Maake C, Bar W, Kratzer A . mRNA profiling for body fluid identification by reverse transcription endpoint PCR and realtime PCR. Forensic Sci Int Genet. 2009; 3(2):80-8. DOI: 10.1016/j.fsigen.2008.11.003. View

17.

Giannobile W, Beikler T, Kinney J, Ramseier C, Morelli T, Wong D . Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000. 2009; 50:52-64. PMC: 5695225. DOI: 10.1111/j.1600-0757.2008.00288.x. View

18.

Katakura A, Kamiyama I, Takano N, Shibahara T, Muramatsu T, Ishihara K . Comparison of salivary cytokine levels in oral cancer patients and healthy subjects. Bull Tokyo Dent Coll. 2008; 48(4):199-203. DOI: 10.2209/tdcpublication.48.199. View

19.

Castro M, Elias P, Martinelli Jr C, Antonini S, Santiago L, Moreira A . Salivary cortisol as a tool for physiological studies and diagnostic strategies. Braz J Med Biol Res. 2000; 33(10):1171-5. DOI: 10.1590/s0100-879x2000001000006. View

20.

Wei F, Patel P, Liao W, Chaudhry K, Zhang L, Arellano-Garcia M . Electrochemical sensor for multiplex biomarkers detection. Clin Cancer Res. 2009; 15(13):4446-52. PMC: 2799532. DOI: 10.1158/1078-0432.CCR-09-0050. View