Benign Painful Elbow Syndrome. First Results of a Single Center Prospective Randomized Radiotherapy Dose Optimization Trial

Overview

Journal Strahlenther Onkol

Specialties Oncology
Radiology

Date 2012 Aug 25

PMID 22918610

Citations 13

Authors

O J Ott

S Hertel

U S Gaipl

B Frey

M Schmidt

R Fietkau

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: The goal of the present study was to evaluate the efficacy of two different dose-fractionation schedules for radiotherapy (RT) of patients with painful elbow syndrome.

Patients And Methods: Between February 2006 and February 2010, 199 consecutive evaluable patients were recruited for this prospective randomized trial. All patients received RT in orthovoltage technique. One RT course consisted of 6 single fractions/3 weeks. In case of insufficient remission of pain after 6 weeks a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. Endpoint was pain reduction. Pain was measured before, right after, and 6 weeks after RT by a visual analogue scale (VAS) and a comprehensive pain score (CPS).

Results: The overall response rate for all patients was 80% direct after and 91% 6 weeks after RT. The mean VAS values before, after and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 59.6 ± 20.2 and 55.7 ± 18.0 (p = 0.463), 32.1 ± 24.5 and 34.4 ± 22.5 (p = 0.256), and 27.0 ± 27.7 and 23.5 ± 21.6 (p = 0.818). The mean CPS before, after, and 6 weeks after treatment was 8.7 ± 2.9 and 8.1 ± 3.1 (p = 0.207), 4.5 ± 3.2 and 5.0 ± 3.4 (p = 0.507), 3.9 ± 3.6 and 2.8 ± 2.8 (p = 0.186), respectively. No statistically significant differences between the two single dose trial arms for early (p = 0.103) and delayed response (p = 0.246) were found.

Conclusion: RT is an effective treatment option for the management of benign painful elbow syndrome. For radiation protection reasons the dose for a RT series is recommended not to exceed 3.0 Gy.

Citing Articles

The role of radiation treatment in the management of inflammatory musculoskeletal conditions: a revisit.

Abdus-Salam A, Olabumuyi A, Jimoh M, Folorunso S, Orekoya A Radiat Oncol J. 2020; 38(3):151-161.

PMID: 33012142 PMC: 7533403. DOI: 10.3857/roj.2020.00178.

Prospective Evaluation of Changes in Pain Levels, Quality of Life and Functionality After Low Dose Radiotherapy for Epicondylitis, Plantar Fasciitis, and Finger Osteoarthritis.

Rogers S, Eberle B, Vogt D, Meier E, Moser L, Gomez Ordonez S Front Med (Lausanne). 2020; 7:195.

PMID: 32509794 PMC: 7249275. DOI: 10.3389/fmed.2020.00195.

Radiotherapy of epicondylitis humeri : Analysis of 138 elbows treated with a linear accelerator.

Hautmann M, Beyer L, Suss C, Neumaier U, Steger F, Putz F Strahlenther Onkol. 2018; 195(4):343-351.

PMID: 30426149 DOI: 10.1007/s00066-018-1397-9.

Radiotherapy for benign achillodynia. Long-term results of the Erlangen Dose Optimization Trial.

Ott O, Jeremias C, Gaipl U, Frey B, Schmidt M, Fietkau R Strahlenther Onkol. 2015; 191(12):979-84.

PMID: 26369640 DOI: 10.1007/s00066-015-0893-4.

Radiotherapy for non-malignant disorders: state of the art and update of the evidence-based practice guidelines.

Seegenschmiedt M, Micke O, Muecke R Br J Radiol. 2015; 88(1051):20150080.

PMID: 25955230 PMC: 4628533. DOI: 10.1259/bjr.20150080.

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