A Review of Local Anesthetic Cardiotoxicity and Treatment with Lipid Emulsion

Overview

Journal Local Reg Anesth

Publisher Dove Medical Press

Date 2012 Aug 24

PMID 22915863

Citations 15

Authors

Emma Bourne

Christine Wright

Colin Royse

Affiliations

Soon will be listed here.

Abstract

Cardiovascular collapse from accidental local anesthetic toxicity is a rare but catastrophic complication of regional anesthesia. The long-acting amide local anesthetics bupivacaine, levobupivacaine and ropivacaine have differential cardiac toxicity, but all are capable of causing death with accidental overdose. In recent times, the chance discovery that lipid emulsion may improve the chance of successful resuscitation has lead to recommendations that it should be available in every location where regional anesthesia is performed. This review will outline the mechanisms of local anesthetic toxicity and the rationale for lipid emulsion therapy.

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