Partitioning the Heart: Mechanisms of Cardiac Septation and Valve Development

Overview

Journal Development

Specialty Biology

Date 2012 Aug 23

PMID 22912411

Citations 109

Authors

Chien-Jung Lin

Chieh-Yu Lin

Chen-Hao Chen

Bin Zhou

Ching-Pin Chang

Affiliations

Soon will be listed here.

Abstract

Heart malformations are common congenital defects in humans. Many congenital heart defects involve anomalies in cardiac septation or valve development, and understanding the developmental mechanisms that underlie the formation of cardiac septal and valvular tissues thus has important implications for the diagnosis, prevention and treatment of congenital heart disease. The development of heart septa and valves involves multiple types of progenitor cells that arise either within or outside the heart. Here, we review the morphogenetic events and genetic networks that regulate spatiotemporal interactions between the cells that give rise to septal and valvular tissues and hence partition the heart.

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