Peroxidasin: Tying the Collagen-sulfilimine Knot

Overview

Journal Nat Chem Biol

Specialties Biochemistry
Biology
Chemistry

Date 2012 Aug 22

PMID 22907088

Citations 6

Authors

Stephen J Weiss

Affiliations

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Abstract

Type IV collagen, a major constituent of basement membranes, contains an unusual intermolecular sulfilimine crosslink whose route of biosynthesis has remained undefined. An oxidative triad consisting of peroxidasin, H(2)O(2) and halide is now shown to drive sulfilimine generation in vivo.

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Selective Synthesis of -Cyano Sulfilimines by Dearomatizing Stable Thionium Ions.

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Peroxidase-catalysed interfacial adhesion of aquatic caddisworm silk.

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A role for peroxidasin PXN-1 in aspects of C. elegans development.

Lee J, Bandyopadhyay J, Il Lee J, Cho I, Park D, Cho J Mol Cells. 2014; 38(1):51-7.

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A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.

Fidler A, Vanacore R, Chetyrkin S, Pedchenko V, Bhave G, Yin V Proc Natl Acad Sci U S A. 2013; 111(1):331-6.

PMID: 24344311 PMC: 3890831. DOI: 10.1073/pnas.1318499111.

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