Glutathione Levels in Human Tumors

Overview

Journal Biomarkers

Specialty Biochemistry

Date 2012 Aug 21

PMID 22900535

Citations 191

Authors

Michael P Gamcsik

Mohit S Kasibhatla

Stephanie D Teeter

O Michael Colvin

Affiliations

Soon will be listed here.

Abstract

This review summarizes clinical studies in which glutathione was measured in tumor tissue from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung cancer. Glutathione tends to be elevated in breast, ovarian, head and neck, and lung cancer and lower in brain and liver tumors compared to disease-free tissue. Cervical, colorectal, gastric, and esophageal cancers show both higher and lower levels of tumor glutathione. Some studies show an inverse relationship between patient survival and tumor glutathione. Based on this survey, we recommend approaches that may improve the clinical value of glutathione as a biomarker.

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