Hereditary Hemochromatosis Restores the Virulence of Plague Vaccine Strains

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2012 Aug 17

PMID 22896664

Citations 34

Authors

Lauriane E Quenee

Timothy M Hermanas

Nancy Ciletti

Helene Louvel

Nathan C Miller

Derek Elli

Bill Blaylock

Anthony Mitchell

Jay Schroeder

Thomas Krausz

Joseph Kanabrocki

Olaf Schneewind

Affiliations

Soon will be listed here.

Abstract

Nonpigmented Yersinia pestis (pgm) strains are defective in scavenging host iron and have been used in live-attenuated vaccines to combat plague epidemics. Recently, a Y. pestis pgm strain was isolated from a researcher with hereditary hemochromatosis who died from laboratory-acquired plague. We used hemojuvelin-knockout (Hjv(-/-)) mice to examine whether iron-storage disease restores the virulence defects of nonpigmented Y. pestis. Unlike wild-type mice, Hjv(-/-) mice developed lethal plague when challenged with Y. pestis pgm strains. Immunization of Hjv(-/-) mice with a subunit vaccine that blocks Y. pestis type III secretion generated protection against plague. Thus, individuals with hereditary hemochromatosis may be protected with subunit vaccines but should not be exposed to live-attenuated plague vaccines.

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