Cellular Mechanisms of Aortic Valve Calcification

Overview

Journal Circ Cardiovasc Interv

Specialty Cardiology & Vascular Diseases

Date 2012 Aug 17

PMID 22896576

Citations 109

Authors

Jane A Leopold

Affiliations

Soon will be listed here.

Citing Articles

Transcatheter Aortic Valve Implantation (TAVI) in Bicuspid Anatomy.

Nikas D, Lakkas L, Naka K, Michalis L J Clin Med. 2025; 14(3).

PMID: 39941442 PMC: 11818256. DOI: 10.3390/jcm14030772.

Mineral composition and ratios in aortic valves, serum, and epicardial fat among patients with aortic stenosis undergoing aortic valve replacement.

Poniedzialek B, Perek B, Proch A, Komosa A, Niedzielski P, Buczkowski P Sci Rep. 2025; 15(1):1233.

PMID: 39775052 PMC: 11707200. DOI: 10.1038/s41598-025-85141-9.

The Implications of Aging on Vascular Health.

Ahmed B, Rahman A, Lee S, Malhotra R Int J Mol Sci. 2024; 25(20).

PMID: 39456971 PMC: 11508873. DOI: 10.3390/ijms252011188.

A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression.

Tandon I, Woessner A, Ferreira L, Shamblin C, Vaca-Diez G, Walls A Acta Biomater. 2024; 186:167-184.

PMID: 39084496 PMC: 11702842. DOI: 10.1016/j.actbio.2024.07.036.

Immunotherapy in the Context of Aortic Valve Diseases.

Bartoli-Leonard F, Pennel T, Caputo M Cardiovasc Drugs Ther. 2024; 38(6):1173-1185.

PMID: 39017904 PMC: 11680629. DOI: 10.1007/s10557-024-07608-7.

References

Alexopoulos A, Bravou V, Peroukides S, Kaklamanis L, Varakis J, Alexopoulos D . Bone regulatory factors NFATc1 and Osterix in human calcific aortic valves. Int J Cardiol. 2008; 139(2):142-9. DOI: 10.1016/j.ijcard.2008.10.014. View

Caira F, Stock S, Gleason T, McGee E, Huang J, Bonow R . Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol. 2006; 47(8):1707-12. PMC: 3951851. DOI: 10.1016/j.jacc.2006.02.040. View

Kaden J, Dempfle C, Grobholz R, Fischer C, Vocke D, Kilic R . Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovasc Pathol. 2005; 14(2):80-7. DOI: 10.1016/j.carpath.2005.01.002. View

Chen J, Yin Yip C, Sone E, Simmons C . Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Pathol. 2009; 174(3):1109-19. PMC: 2665769. DOI: 10.2353/ajpath.2009.080750. View

Rabkin E, Aikawa M, Stone J, Fukumoto Y, Libby P, Schoen F . Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation. 2001; 104(21):2525-32. DOI: 10.1161/hc4601.099489. View

Smits P, van Geuns R, Poldermans D, Bountioukos M, Onderwater E, Lee C . Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J Am Coll Cardiol. 2003; 42(12):2063-9. DOI: 10.1016/j.jacc.2003.06.017. View

Schoppet M, Kavurma M, Hofbauer L, Shanahan C . Crystallizing nanoparticles derived from vascular smooth muscle cells contain the calcification inhibitor osteoprotegerin. Biochem Biophys Res Commun. 2011; 407(1):103-7. DOI: 10.1016/j.bbrc.2011.02.117. View

Peltonen T, Napankangas J, Vuolteenaho O, Ohtonen P, Soini Y, Juvonen T . Apelin and its receptor APJ in human aortic valve stenosis. J Heart Valve Dis. 2010; 18(6):644-52. View

Chakraborty S, Wirrig E, Hinton R, Merrill W, Spicer D, Yutzey K . Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves. Dev Biol. 2010; 347(1):167-79. PMC: 2950232. DOI: 10.1016/j.ydbio.2010.08.021. View

10.

Wuthier R, Lipscomb G . Matrix vesicles: structure, composition, formation and function in calcification. Front Biosci (Landmark Ed). 2011; 16(8):2812-902. DOI: 10.2741/3887. View

11.

Hajdu Z, Romeo S, Fleming P, Markwald R, Visconti R, Drake C . Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process. J Mol Cell Cardiol. 2011; 51(6):955-65. PMC: 3208774. DOI: 10.1016/j.yjmcc.2011.08.006. View

12.

Cowell S, Newby D, Prescott R, Bloomfield P, Reid J, Northridge D . A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med. 2005; 352(23):2389-97. DOI: 10.1056/NEJMoa043876. View

13.

Cagirci G, Cay S, Karakurt O, Durmaz T, Yazihan N, Canga A . Paraoxonase activity might be predictive of the severity of aortic valve stenosis. J Heart Valve Dis. 2010; 19(4):453-8. View

14.

Yin Yip C, Chen J, Zhao R, Simmons C . Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol. 2009; 29(6):936-42. DOI: 10.1161/ATVBAHA.108.182394. View

15.

Combs M, Yutzey K . Heart valve development: regulatory networks in development and disease. Circ Res. 2009; 105(5):408-21. PMC: 2777683. DOI: 10.1161/CIRCRESAHA.109.201566. View

16.

Chen J, Simmons C . Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues. Circ Res. 2011; 108(12):1510-24. DOI: 10.1161/CIRCRESAHA.110.234237. View

17.

Sorescu G, Song H, Tressel S, Hwang J, Dikalov S, Smith D . Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Circ Res. 2004; 95(8):773-9. DOI: 10.1161/01.RES.0000145728.22878.45. View

18.

Schoen F . Mechanisms of function and disease of natural and replacement heart valves. Annu Rev Pathol. 2011; 7:161-83. DOI: 10.1146/annurev-pathol-011110-130257. View

19.

Owens D, Katz R, Takasu J, Kronmal R, Budoff M, OBrien K . Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA). Am J Cardiol. 2010; 105(5):701-8. PMC: 2829478. DOI: 10.1016/j.amjcard.2009.10.071. View

20.

Bostrom K, Rajamannan N, Towler D . The regulation of valvular and vascular sclerosis by osteogenic morphogens. Circ Res. 2011; 109(5):564-77. PMC: 3167074. DOI: 10.1161/CIRCRESAHA.110.234278. View