Plasma MicroRNA-21 Concentration May Be a Useful Biomarker in Glioblastoma Patients

Overview

Journal Cancer Invest

Specialty Oncology

Date 2012 Aug 16

PMID 22891879

Citations 33

Authors

Aysegul Ilhan-Mutlu

Ludwig Wagner

Adelheid Wohrer

Julia Furtner

Georg Widhalm

Christine Marosi

Matthias Preusser

Affiliations

Soon will be listed here.

Abstract

Background: MicroRNAs are proposed as plasma biomarkers in cancer. Glioblastoma is the most frequent primary brain tumor of adults. MicroRNA-21 was shown to induce glioblastoma growth.

Aims: To evaluate the circulating microRNA-21 in glioblastoma patients.

Methods: MicroRNA-21 copies in glioblastoma plasma (n = 10, before surgery and during/after concomitant chemoradiotherapy), control plasma (n = 10), and tissue samples were analyzed using RT-qPCR.

Results: MicroRNA-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). One patient with increasing microRNA-21 developed a histopathologically proven recurrence after the second sample collection.

Discussion: Circulating microRNA-21 might be a useful biomarker in glioblastoma.

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Ali H, Harting R, de Vries R, Ali M, Wurdinger T, Best M Front Oncol. 2021; 11:665235.

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