Physicochemical Modulation of Skin Barrier by Microwave for Transdermal Drug Delivery

Overview

Journal Pharm Res

Specialties Pharmacology
Pharmacy

Date 2012 Aug 15

PMID 22890987

Citations 3

Authors

Tin Wui Wong

Anuar Nor Khaizan

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate mechanism of microwave enhancing drug permeation transdermally through its action on skin.

Methods: Hydrophilic pectin-sulphanilamide films, with or without oleic acid (OA), were subjected to drug release and skin permeation studies. The skins were untreated or microwave-treated, and characterized by infrared spectroscopy, Raman spectroscopy, thermal, electron microscopy and histology techniques.

Results: Skin treatment by microwave at 2450 MHz for 5 min promoted drug permeation from OA-free film without incurring skin damage. Skin treatment by microwave followed by film loaded with drug and OA resulted in permeation of all drug molecules that were released from film. Microwave exerted spacing of lipid architecture of stratum corneum into structureless domains which was unattainable by OA. It allowed OA to permeate stratum corneum and accumulate in dermis at a greater ease, and synergistically inducing lipid/keratin fluidization at hydrophobic C-H and hydrophilic O-H, N-H, C-O, C=O, C-N regimes of skin, and promoting drug permeation.

Conclusion: The microwave technology is evidently feasible for use in promotion of drug permeation across the skin barrier. It represents a new approach in transdermal drug delivery.

Citing Articles

How physical techniques improve the transdermal permeation of therapeutics: A review.

Gao Y, Du L, Li Q, Li Q, Zhu L, Yang M Medicine (Baltimore). 2022; 101(26):e29314.

PMID: 35777055 PMC: 9239599. DOI: 10.1097/MD.0000000000029314.

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Current advances in transdermal delivery of drugs for Alzheimer's disease.

Nguyen T, Giau V, Vo T Indian J Pharmacol. 2017; 49(2):145-154.

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