Non-injection and Injection Drug Use and STI/HIV Risk in the United States: the Degree to Which Sexual Risk Behaviors Versus Sex with an STI-infected Partner Account for Infection Transmission Among Drug Users

Overview

Journal AIDS Behav

Specialty Infectious Diseases

Date 2012 Aug 15

PMID 22890684

Citations 55

Authors

Maria R Khan

Amanda Berger

Jordana Hemberg

Allison ONeill

Typhanye Penniman Dyer

Kristina Smyrk

Affiliations

Soon will be listed here.

Abstract

We used the National Longitudinal Study of Adolescent Health (N = 14,322) to measure associations between non-injection crack-cocaine and injection drug use and sexually transmitted infection including HIV (STI/HIV) risk among young adults in the United States and to identify factors that mediate the relationship between drug use and infection. Respondents were categorized as injection drug users, non-injection crack-cocaine users, or non-users of crack-cocaine or injection drugs. Non-injection crack-cocaine use remained an independent correlate of STI when adjusting for age at first sex and socio-demographic characteristics (adjusted prevalence ratio (APR): 1.64, 95 % confidence interval (CI): 1.16-2.31) and sexual risk behaviors including multiple partnerships and inconsistent condom use. Injection drug use was strongly associated with STI (APR: 2.62, 95 % CI: 1.29-5.33); this association appeared to be mediated by sex with STI-infected partners rather than by sexual risk behaviors. The results underscore the importance of sexual risk reduction among all drug users including IDUs, who face high sexual as well as parenteral transmission risk.

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References

Cohen M . HIV and sexually transmitted diseases: lethal synergy. Top HIV Med. 2004; 12(4):104-7. View

Friedman S, Bolyard M, Maslow C, Mateu-Gelabert P, Sandoval M . Harnessing the power of social networks to reduce HIV risk. Focus. 2005; 20(1):5-6. View

Ross M, Williams M . Sexual behavior and illicit drug use. Annu Rev Sex Res. 2003; 12:290-310. View

Koumans E, Johnson R, Knapp J, St Louis M . Laboratory testing for Neisseria gonorrhoeae by recently introduced nonculture tests: a performance review with clinical and public health considerations. Clin Infect Dis. 1998; 27(5):1171-80. DOI: 10.1086/514994. View

Des Jarlais D, Arasteh K, McKnight C, Hagan H, Perlman D, Friedman S . Using hepatitis C virus and herpes simplex virus-2 to track HIV among injecting drug users in New York City. Drug Alcohol Depend. 2008; 101(1-2):88-91. DOI: 10.1016/j.drugalcdep.2008.11.007. View

Shrem M, Halkitis P . Methamphetamine abuse in the United States: contextual, psychological and sociological considerations. J Health Psychol. 2008; 13(5):669-79. DOI: 10.1177/1359105307082461. View

Kral A, Bluthenthal R, Lorvick J, Gee L, Bacchetti P, Edlin B . Sexual transmission of HIV-1 among injection drug users in San Francisco, USA: risk-factor analysis. Lancet. 2001; 357(9266):1397-401. DOI: 10.1016/S0140-6736(00)04562-1. View

Cohen M . Sexually transmitted diseases enhance HIV transmission: no longer a hypothesis. Lancet. 1998; 351 Suppl 3:5-7. DOI: 10.1016/s0140-6736(98)90002-2. View

Hwang L, Ross M, Zack C, Bull L, Rickman K, Holleman M . Prevalence of sexually transmitted infections and associated risk factors among populations of drug abusers. Clin Infect Dis. 2000; 31(4):920-6. DOI: 10.1086/318131. View

10.

Adimora A, Schoenbach V, Martinson F, Coyne-Beasley T, Doherty I, Stancil T . Heterosexually transmitted HIV infection among African Americans in North Carolina. J Acquir Immune Defic Syndr. 2006; 41(5):616-23. DOI: 10.1097/01.qai.0000191382.62070.a5. View

11.

Wasserheit J . Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Sex Transm Dis. 1992; 19(2):61-77. View

12.

Gust D, Levine W, St Louis M, Braxton J, Berman S . Mortality associated with congenital syphilis in the United States, 1992-1998. Pediatrics. 2002; 109(5):E79-9. DOI: 10.1542/peds.109.5.e79. View

13.

Weinstock H, Berman S, Cates Jr W . Sexually transmitted diseases among American youth: incidence and prevalence estimates, 2000. Perspect Sex Reprod Health. 2004; 36(1):6-10. DOI: 10.1363/psrh.36.6.04. View

14.

Nusbaum M, Wallace R, Slatt L, Kondrad E . Sexually transmitted infections and increased risk of co-infection with human immunodeficiency virus. J Am Osteopath Assoc. 2005; 104(12):527-35. View

15.

Lejuez C, Bornovalova M, Daughters S, Curtin J . Differences in impulsivity and sexual risk behavior among inner-city crack/cocaine users and heroin users. Drug Alcohol Depend. 2005; 77(2):169-75. DOI: 10.1016/j.drugalcdep.2004.08.013. View

16.

Friedman S, Flom P, Kottiri B, Zenilman J, Curtis R, Neaigus A . Drug use patterns and infection with sexually transmissible agents among young adults in a high-risk neighbourhood in New York City. Addiction. 2003; 98(2):159-69. DOI: 10.1046/j.1360-0443.2003.00271.x. View

17.

Strathdee S, Sherman S . The role of sexual transmission of HIV infection among injection and non-injection drug users. J Urban Health. 2004; 80(4 Suppl 3):iii7-14. PMC: 3456264. DOI: 10.1093/jurban/jtg078. View

18.

Darke S, Kaye S, McKetin R, Duflou J . Major physical and psychological harms of methamphetamine use. Drug Alcohol Rev. 2008; 27(3):253-62. DOI: 10.1080/09595230801923702. View

19.

McNutt L, Wu C, Xue X, Hafner J . Estimating the relative risk in cohort studies and clinical trials of common outcomes. Am J Epidemiol. 2003; 157(10):940-3. DOI: 10.1093/aje/kwg074. View

20.

Miller M, Liao Y, Wagner M, Korves C . HIV, the clustering of sexually transmitted infections, and sex risk among African American women who use drugs. Sex Transm Dis. 2008; 35(7):696-702. DOI: 10.1097/OLQ.0b013e31816b1fb8. View