Novel Insights into the Role of S100A8/A9 in Skin Biology

Overview

Journal Exp Dermatol

Specialty Dermatology

Date 2012 Aug 14

PMID 22882537

Citations 58

Authors

Claus Kerkhoff

Andreas Voss

Thomas E Scholzen

Michelle M Averill

Kurt S Zanker

Karin E Bornfeldt

Affiliations

Soon will be listed here.

Abstract

S100A8 and S100A9 belong to the damage-associated molecular pattern molecules. They are upregulated in a number of inflammatory skin disorders. Owing to their abundance in myeloid cells, the main function of S100A8/A9 has been attributed to their role in inflammatory cells. However, it is becoming increasingly clear that they also exert important roles in epithelial cells. In this review, we discuss the context-dependent function of S100A8/A9 in epithelial cells and their impact on wound healing, psoriasis and other skin diseases.

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