Closed-loop Control of Epilepsy by Transcranial Electrical Stimulation

Overview

Journal Science

Specialty Science

Date 2012 Aug 11

PMID 22879515

Citations 169

Authors

Antal Berenyi

Mariano Belluscio

Dun Mao

Gyorgy Buzsaki

Affiliations

Soon will be listed here.

Abstract

Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.

Citing Articles

Hydrogels in wearable neural interfaces.

Yao M, Hsieh J, Tang K, Wang H Med X. 2024; 2(1):23.

PMID: 39659711 PMC: 11625692. DOI: 10.1007/s44258-024-00040-4.

Magnetic field in the extreme low frequency band protects neuronal and microglia cells from oxygen-glucose deprivation.

Mata P, Calovi S, Benli K, Iglesias L, Hernandez M, Martin A Front Cell Neurosci. 2024; 18:1455158.

PMID: 39553829 PMC: 11563784. DOI: 10.3389/fncel.2024.1455158.

Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice.

Shannon T, Levine N, Dirickson R, Shen Y, Cotter C, Rajjoub N Front Neurosci. 2024; 18:1422449.

PMID: 39268032 PMC: 11390562. DOI: 10.3389/fnins.2024.1422449.

Neuroprotective Efficacy and Complementary Treatment with Medicinal Herbs: A Comprehensive Review of Recent Therapeutic Approaches in Epilepsy Management.

Anand A, Shrivastava A, Singh K, Barik R, Gayakwad D, S J CNS Neurol Disord Drug Targets. 2024; 24(1):60-73.

PMID: 39069797 DOI: 10.2174/0118715273332140240724093837.

The bidirectional relationship between the cerebellum and seizure networks: a double-edged sword.

Streng M Curr Opin Behav Sci. 2024; 54.

PMID: 38800711 PMC: 11126210. DOI: 10.1016/j.cobeha.2023.101327.

References

Ozen S, Sirota A, Belluscio M, Anastassiou C, Stark E, Koch C . Transcranial electric stimulation entrains cortical neuronal populations in rats. J Neurosci. 2010; 30(34):11476-85. PMC: 2937280. DOI: 10.1523/JNEUROSCI.5252-09.2010. View

Kandel A, Buzsaki G . Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat. J Neurosci. 1997; 17(17):6783-97. PMC: 6573130. View

Schiff S, Jerger K, Duong D, Chang T, Spano M, Ditto W . Controlling chaos in the brain. Nature. 1994; 370(6491):615-20. DOI: 10.1038/370615a0. View

Varga E, Terney D, Atkins M, Nikanorova M, Jeppesen D, Uldall P . Transcranial direct current stimulation in refractory continuous spikes and waves during slow sleep: a controlled study. Epilepsy Res. 2011; 97(1-2):142-5. DOI: 10.1016/j.eplepsyres.2011.07.016. View

Steriade M . Sleep, epilepsy and thalamic reticular inhibitory neurons. Trends Neurosci. 2005; 28(6):317-24. DOI: 10.1016/j.tins.2005.03.007. View

Joundi R, Jenkinson N, Brittain J, Aziz T, Brown P . Driving oscillatory activity in the human cortex enhances motor performance. Curr Biol. 2012; 22(5):403-7. PMC: 3343257. DOI: 10.1016/j.cub.2012.01.024. View

Kostopoulos G, Gloor P, Pellegrini A, Gotman J . A study of the transition from spindles to spike and wave discharge in feline generalized penicillin epilepsy: microphysiological features. Exp Neurol. 1981; 73(1):55-77. DOI: 10.1016/0014-4886(81)90045-5. View

Najib U, Bashir S, Edwards D, Rotenberg A, Pascual-Leone A . Transcranial brain stimulation: clinical applications and future directions. Neurosurg Clin N Am. 2011; 22(2):233-51, ix. PMC: 3547606. DOI: 10.1016/j.nec.2011.01.002. View

Hughes J . Absence seizures: a review of recent reports with new concepts. Epilepsy Behav. 2009; 15(4):404-12. DOI: 10.1016/j.yebeh.2009.06.007. View

10.

Girardeau G, Benchenane K, Wiener S, Buzsaki G, Zugaro M . Selective suppression of hippocampal ripples impairs spatial memory. Nat Neurosci. 2009; 12(10):1222-3. DOI: 10.1038/nn.2384. View

11.

Marescaux C, VERGNES M, Depaulis A . Genetic absence epilepsy in rats from Strasbourg--a review. J Neural Transm Suppl. 1992; 35:37-69. DOI: 10.1007/978-3-7091-9206-1_4. View

12.

Frohlich F, McCormick D . Endogenous electric fields may guide neocortical network activity. Neuron. 2010; 67(1):129-43. PMC: 3139922. DOI: 10.1016/j.neuron.2010.06.005. View

13.

Fisher R . Therapeutic devices for epilepsy. Ann Neurol. 2012; 71(2):157-68. PMC: 3296971. DOI: 10.1002/ana.22621. View

14.

Makeyev O, Liu X, Koka K, Kay S, Besio W . Transcranial focal stimulation via concentric ring electrodes reduced power of pentylenetetrazole-induced seizure activity in rat electroencephalogram. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2011:7560-3. DOI: 10.1109/IEMBS.2011.6091864. View

15.

Marshall L, Helgadottir H, Molle M, Born J . Boosting slow oscillations during sleep potentiates memory. Nature. 2006; 444(7119):610-3. DOI: 10.1038/nature05278. View

16.

Rotenberg A, Pascual-Leone A . Safety of 1 Hz repetitive transcranial magnetic stimulation (rTMS) in patients with titanium skull plates. Clin Neurophysiol. 2009; 120(7):1417. DOI: 10.1016/j.clinph.2009.05.004. View

17.

Mayberg H, Lozano A, Voon V, McNeely H, Seminowicz D, Hamani C . Deep brain stimulation for treatment-resistant depression. Neuron. 2005; 45(5):651-60. DOI: 10.1016/j.neuron.2005.02.014. View

18.

Motamedi G, Lesser R, Miglioretti D, Mizuno-Matsumoto Y, Gordon B, Webber W . Optimizing parameters for terminating cortical afterdischarges with pulse stimulation. Epilepsia. 2002; 43(8):836-46. DOI: 10.1046/j.1528-1157.2002.24901.x. View

19.

Perlmutter J, Mink J . Deep brain stimulation. Annu Rev Neurosci. 2006; 29:229-57. PMC: 4518728. DOI: 10.1146/annurev.neuro.29.051605.112824. View

20.

Rosin B, Slovik M, Mitelman R, Rivlin-Etzion M, Haber S, Israel Z . Closed-loop deep brain stimulation is superior in ameliorating parkinsonism. Neuron. 2011; 72(2):370-84. DOI: 10.1016/j.neuron.2011.08.023. View