Strain Estimation in Phase-sensitive Optical Coherence Elastography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2012 Aug 10

PMID 22876350

Citations 62

Authors

Brendan F Kennedy

Sze Howe Koh

Robert A McLaughlin

Kelsey M Kennedy

Peter R T Munro

David D Sampson

Affiliations

Soon will be listed here.

Abstract

We present a theoretical framework for strain estimation in optical coherence elastography (OCE), based on a statistical analysis of displacement measurements obtained from a mechanically loaded sample. We define strain sensitivity, signal-to-noise ratio and dynamic range, and derive estimates of strain using three methods: finite difference, ordinary least squares and weighted least squares, the latter implemented for the first time in OCE. We compare theoretical predictions with experimental results and demonstrate a ~12 dB improvement in strain sensitivity using weighted least squares compared to finite difference strain estimation and a ~4 dB improvement over ordinary least squares strain estimation. We present strain images (i.e., elastograms) of tissue-mimicking phantoms and excised porcine airway, demonstrating in each case clear contrast based on the sample's elasticity.

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References

Szkulmowska A, Szkulmowski M, Kowalczyk A, Wojtkowski M . Phase-resolved Doppler optical coherence tomography--limitations and improvements. Opt Lett. 2008; 33(13):1425-7. DOI: 10.1364/ol.33.001425. View

Chan R, Chau A, Karl W, Nadkarni S, Khalil A, Iftimia N . OCT-based arterial elastography: robust estimation exploiting tissue biomechanics. Opt Express. 2009; 12(19):4558-72. DOI: 10.1364/opex.12.004558. View

Han S, El-Abbadi N, Hanna N, Mahmood U, Mina-Araghi R, Jung W . Evaluation of tracheal imaging by optical coherence tomography. Respiration. 2005; 72(5):537-41. DOI: 10.1159/000087680. View

Ophir J, Cespedes I, Ponnekanti H, Yazdi Y, Li X . Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging. 1991; 13(2):111-34. DOI: 10.1177/016173469101300201. View

Kennedy B, Hillman T, Curatolo A, Sampson D . Speckle reduction in optical coherence tomography by strain compounding. Opt Lett. 2010; 35(14):2445-7. DOI: 10.1364/OL.35.002445. View

Hillman T, Curatolo A, Kennedy B, Sampson D . Detection of multiple scattering in optical coherence tomography by speckle correlation of angle-dependent B-scans. Opt Lett. 2010; 35(12):1998-2000. DOI: 10.1364/OL.35.001998. View

Schmitt J . OCT elastography: imaging microscopic deformation and strain of tissue. Opt Express. 2009; 3(6):199-211. DOI: 10.1364/oe.3.000199. View

Rains J, Bert J, Roberts C, Pare P . Mechanical properties of human tracheal cartilage. J Appl Physiol (1985). 1992; 72(1):219-25. DOI: 10.1152/jappl.1992.72.1.219. View

Pircher M, Baumann B, Gotzinger E, Sattmann H, Hitzenberger C . Phase contrast coherence microscopy based on transverse scanning. Opt Lett. 2009; 34(12):1750-2. PMC: 2956977. DOI: 10.1364/ol.34.001750. View

10.

Park B, Pierce M, Cense B, Yun S, Mujat M, Tearney G . Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 microm. Opt Express. 2009; 13(11):3931-44. DOI: 10.1364/opex.13.003931. View

11.

Ko H, Tan W, Stack R, Boppart S . Optical coherence elastography of engineered and developing tissue. Tissue Eng. 2006; 12(1):63-73. DOI: 10.1089/ten.2006.12.63. View

12.

Kennedy B, Curatolo A, Hillman T, Saunders C, Sampson D . Speckle reduction in optical coherence tomography images using tissue viscoelasticity. J Biomed Opt. 2011; 16(2):020506. DOI: 10.1117/1.3548239. View

13.

Rogowska J, Patel N, Fujimoto J, Brezinski M . Optical coherence tomographic elastography technique for measuring deformation and strain of atherosclerotic tissues. Heart. 2004; 90(5):556-62. PMC: 1768234. DOI: 10.1136/hrt.2003.016956. View

14.

Ophir J, Alam S, Garra B, Kallel F, Konofagou E, Krouskop T . Elastography: ultrasonic estimation and imaging of the elastic properties of tissues. Proc Inst Mech Eng H. 1999; 213(3):203-33. DOI: 10.1243/0954411991534933. View

15.

Adie S, Liang X, Kennedy B, John R, Sampson D, Boppart S . Spectroscopic optical coherence elastography. Opt Express. 2010; 18(25):25519-34. PMC: 3319753. DOI: 10.1364/OE.18.025519. View

16.

Varghese T, Ophir J . A theoretical framework for performance characterization of elastography: the strain filter. IEEE Trans Ultrason Ferroelectr Freq Control. 1997; 44(1):164-72. DOI: 10.1109/58.585212. View

17.

Greenleaf J, Fatemi M, Insana M . Selected methods for imaging elastic properties of biological tissues. Annu Rev Biomed Eng. 2003; 5:57-78. DOI: 10.1146/annurev.bioeng.5.040202.121623. View

18.

Adie S, Kennedy B, Armstrong J, Alexandrov S, Sampson D . Audio frequency in vivo optical coherence elastography. Phys Med Biol. 2009; 54(10):3129-39. DOI: 10.1088/0031-9155/54/10/011. View

19.

Tearney G, Brezinski M, Bouma B, Boppart S, Pitris C, Southern J . In vivo endoscopic optical biopsy with optical coherence tomography. Science. 1997; 276(5321):2037-9. DOI: 10.1126/science.276.5321.2037. View

20.

Kennedy B, Hillman T, McLaughlin R, Quirk B, Sampson D . In vivo dynamic optical coherence elastography using a ring actuator. Opt Express. 2009; 17(24):21762-72. DOI: 10.1364/OE.17.021762. View