Association Between Cataract and Genetic Polymorphisms of GSTM1, GSTT1, and GSTO2 with Respect of Work Place

Overview

Journal Mol Vis

Specialties Cell Biology
Molecular Biology
Ophthalmology

Date 2012 Aug 10

PMID 22876127

Citations 8

Authors

Iraj Saadat

Zainab Ahmadi

Majid Farvardin-Jahromi

Mostafa Saadat

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate whether genetic polymorphisms of glutathione S-transferases (GSTM1, GSTT1, and GSTO2) in relation to the work place contribute to the development of cataract.

Methods: The present case-control study consisted of 186 patients (108 females, 78 males) with cataract and 195 gender-matched healthy controls (111 females, 84 males) were randomly selected from unrelated volunteers in the same clinic. The GSTM1, GSTT1, and GSTO2 genotypes were determined using polymerase chain reaction (PCR) based methods.

Results: The null genotype of GSTM1 increased the risk of cataract (OR=1.51, 95%CI: 1.01-2.26, p=0.045). The prevalence of GSTT1 and GSTO2 genotypes was similar between cases and controls. There was significant difference between cases and controls for work place (χ(2)=4.16, df=1, p=0.041). Genetic polymorphisms (GSTM1, GSTO2) and work place that were significant by p<0.3 in the univariate analysis were included in the analysis for investigating the additive effects of the genotypes and work place on risk of cataract. Statistical analysis showed that the risk of cataract increased as a function of number of putative high risk factors (χ(2)=8.001, p=0.005).

Conclusions: This finding suggests that the polymorphisms of GSTM1 and GSTO2 and also work place may act additively for developing cataract.

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References

Saadat M, Farvardin-Jahromi M . Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk. Occup Environ Med. 2006; 63(7):503-4. PMC: 2092504. DOI: 10.1136/oem.2005.022343. View

Rafiee L, Saadat I, Saadat M . Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. Mol Biol Rep. 2009; 37(1):155-8. DOI: 10.1007/s11033-009-9565-8. View

Mohamadynejad P, Saadat M . Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population (Fars province, southern Iran). Mol Biol Rep. 2007; 35(4):669-72. DOI: 10.1007/s11033-007-9138-7. View

Saadat M, Farvardin-Jahromi M, Saadat H . Null genotype of glutathione S-transferase M1 is associated with senile cataract susceptibility in non-smoker females. Biochem Biophys Res Commun. 2004; 319(4):1287-91. DOI: 10.1016/j.bbrc.2004.05.121. View

Harada S, Misawa S, Nakamura T, Tanaka N, Ueno E, Nozoe M . Detection of GST1 gene deletion by the polymerase chain reaction and its possible correlation with stomach cancer in Japanese. Hum Genet. 1992; 90(1-2):62-4. DOI: 10.1007/BF00210745. View

Saadat M, Ansari-Lari M . Polymorphism of XRCC1 (at codon 399) and susceptibility to breast cancer, a meta-analysis of the literatures. Breast Cancer Res Treat. 2008; 115(1):137-44. DOI: 10.1007/s10549-008-0051-0. View

Kiyohara C, Takayama K, Nakanishi Y . Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis. Lung Cancer. 2006; 54(3):267-83. DOI: 10.1016/j.lungcan.2006.08.009. View

Whitbread A, Tetlow N, Eyre H, Sutherland G, Board P . Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Pharmacogenetics. 2003; 13(3):131-44. DOI: 10.1097/00008571-200303000-00003. View

Pemble S, SCHROEDER K, Spencer S, Meyer D, Hallier E, Bolt H . Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J. 1994; 300 ( Pt 1):271-6. PMC: 1138152. DOI: 10.1042/bj3000271. View

10.

Mukherjee B, Salavaggione O, Pelleymounter L, Moon I, Eckloff B, Schaid D . Glutathione S-transferase omega 1 and omega 2 pharmacogenomics. Drug Metab Dispos. 2006; 34(7):1237-46. DOI: 10.1124/dmd.106.009613. View

11.

Saadat M . Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and susceptibility to gastric cancer: a meta-analysis. Cancer Sci. 2006; 97(6):505-9. PMC: 11158786. DOI: 10.1111/j.1349-7006.2006.00207.x. View

12.

See L, Chiou H, Lee J, Hsueh Y, Lin S, Tu M . Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007; 42(12):1843-51. DOI: 10.1080/10934520701566884. View

13.

Vinson J . Oxidative stress in cataracts. Pathophysiology. 2006; 13(3):151-62. DOI: 10.1016/j.pathophys.2006.05.006. View

14.

Zhang H, Liu P, Yu X, Song Z . [Mechanism of arsenic trioxide induced apoptosis in cultured human lens epithelium cells]. Zhonghua Yan Ke Za Zhi. 2009; 44(10):916-20. View

15.

Shiels A, Hejtmancik J . Genetic origins of cataract. Arch Ophthalmol. 2007; 125(2):165-73. DOI: 10.1001/archopht.125.2.165. View

16.

McCarty C, Taylor H . The genetics of cataract. Invest Ophthalmol Vis Sci. 2001; 42(8):1677-8. View

17.

Hejtmancik J, Kantorow M . Molecular genetics of age-related cataract. Exp Eye Res. 2004; 79(1):3-9. PMC: 1351356. DOI: 10.1016/j.exer.2004.03.014. View

18.

Sun L, Xi B, Yu L, Gao X, Shi D, Yan Y . Association of glutathione S-transferases polymorphisms (GSTM1 and GSTT1) with senile cataract: a meta-analysis. Invest Ophthalmol Vis Sci. 2010; 51(12):6381-6. DOI: 10.1167/iovs.10-5815. View

19.

Ottonello S, Foroni C, Carta A, Petrucco S, Maraini G . Oxidative stress and age-related cataract. Ophthalmologica. 2000; 214(1):78-85. DOI: 10.1159/000027474. View

20.

Hu Z, Ma H, Chen F, Wei Q, Shen H . XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. Cancer Epidemiol Biomarkers Prev. 2005; 14(7):1810-8. DOI: 10.1158/1055-9965.EPI-04-0793. View