Curcumin Suppresses Ovalbumin-induced Allergic Conjunctivitis

Overview

Journal Mol Vis

Specialties Cell Biology
Molecular Biology
Ophthalmology

Date 2012 Aug 10

PMID 22876123

Citations 30

Authors

So-Hyang Chung

Seong Hyun Choi

Jin A Choi

Roy S Chuck

Choun-Ki Joo

Affiliations

Soon will be listed here.

Abstract

Purpose: Allergic conjunctivitis (AC) from an allergen-driven T helper 2 (Th2) response is characterized by conjunctival eosinophilic infiltration. Because curcumin has shown anti-allergic activity in an asthma and contact dermatitis laboratory models, we examined whether administration of curcumin could affect the severity of AC and modify the immune response to ovalbumin (OVA) allergen in an experimental AC model.

Methods: Mice were challenged with two doses of topical OVA via the conjunctival sac after systemic sensitization with OVA in aluminum hydroxide (ALUM). Curcumin was administered 1 h before OVA challenge. Several indicators for allergy such as serum immunoglubulin E (IgE) antibodies production, eosinophil infiltration into the conjunctiva and Th2 cytokine production were evaluated in mice with or without curcumin treatment.

Results: Mice challenged with OVA via the conjunctival sac following systemic sensitization with OVA in ALUM had severe AC. Curcumin administration markedly suppressed IgE-mediated and eosinophil-dependent conjunctival inflammation. In addition, mice administered curcumin had less interleukin-4 (IL-4) and interleukin-5 (IL-5) (Th2 type cytokine) production in conjunctiva, spleen, and cervical lymph nodes than mice in the non-curcumin-administered group. OVA challenge resulted in activation of the production of inducible nitric oxide (iNOS), and curcumin treatment inhibited iNOS production in the conjunctiva.

Conclusions: We believe our findings are the first to demonstrate that curcumin treatment suppresses allergic conjunctival inflammation in an experimental AC model.

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References

Nathan C . Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992; 6(12):3051-64. View

Moon D, Kim M, Lee H, Choi Y, Park Y, Heo M . Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem Biophys Res Commun. 2008; 375(2):275-9. DOI: 10.1016/j.bbrc.2008.08.025. View

Bonini S, Vecchione A, Naim D, ALLANSMITH M, Balsano F . Inflammatory changes in conjunctival scrapings after allergen provocation in humans. J Allergy Clin Immunol. 1988; 82(3 Pt 1):462-9. DOI: 10.1016/0091-6749(88)90020-6. View

Kurup V, Barrios C, Raju R, Johnson B, Levy M, Fink J . Immune response modulation by curcumin in a latex allergy model. Clin Mol Allergy. 2007; 5:1. PMC: 1796894. DOI: 10.1186/1476-7961-5-1. View

Kim G, Kim K, Lee S, Yoon M, Lee H, Moon D . Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol. 2005; 174(12):8116-24. DOI: 10.4049/jimmunol.174.12.8116. View

Hingorani M, Calder V, Jolly G, Buckley R, Lightman S . Eosinophil surface antigen expression and cytokine production vary in different ocular allergic diseases. J Allergy Clin Immunol. 1998; 102(5):821-30. DOI: 10.1016/s0091-6749(98)70023-5. View

Brouet I, Ohshima H . Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Commun. 1995; 206(2):533-40. DOI: 10.1006/bbrc.1995.1076. View

Calder V, Jolly G, Hingorani M, Adamson P, Leonardi A, Secchi A . Cytokine production and mRNA expression by conjunctival T-cell lines in chronic allergic eye disease. Clin Exp Allergy. 1999; 29(9):1214-22. DOI: 10.1046/j.1365-2222.1999.00585.x. View

Metz D, Hingorani M, Calder V, Buckley R, Lightman S . T-cell cytokines in chronic allergic eye disease. J Allergy Clin Immunol. 1998; 100(6 Pt 1):817-24. DOI: 10.1016/s0091-6749(97)70279-3. View

10.

Meijer F, van Delft J, Garrelds I, van Haeringen N, Kijlstra A . Nitric oxide plays a role as a mediator of conjunctival edema in experimental allergic conjunctivitis. Exp Eye Res. 1996; 62(4):359-65. DOI: 10.1006/exer.1996.0041. View

11.

Ko S, Kim M, Kim J . The role of nitric oxide in experimental allergic conjunctivitis. Cornea. 2000; 19(1):84-91. DOI: 10.1097/00003226-200001000-00017. View

12.

Ozaki A, Seki Y, Fukushima A, Kubo M . The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model. J Immunol. 2005; 175(8):5489-97. DOI: 10.4049/jimmunol.175.8.5489. View

13.

Hebestreit H, Dibbert B, Balatti I, Braun D, Schapowal A, Blaser K . Disruption of fas receptor signaling by nitric oxide in eosinophils. J Exp Med. 1998; 187(3):415-25. PMC: 2212112. DOI: 10.1084/jem.187.3.415. View

14.

Fukushima A, Yamaguchi T, Ishida W, Fukata K, Ueno H . TLR2 agonist ameliorates murine experimental allergic conjunctivitis by inducing CD4 positive T-cell apoptosis rather than by affecting the Th1/Th2 balance. Biochem Biophys Res Commun. 2005; 339(4):1048-55. DOI: 10.1016/j.bbrc.2005.11.114. View

15.

Ferreira H, Medeiros M, Lima C, Flores C, Sannomiya P, Autunes E . Inhibition of eosinophil chemotaxis by chronic blockade of nitric oxide biosynthesis. Eur J Pharmacol. 1996; 310(2-3):201-7. DOI: 10.1016/0014-2999(96)00379-2. View

16.

Chung S, Nam K, Kweon M . Staphylococcus aureus accelerates an experimental allergic conjunctivitis by Toll-like receptor 2-dependent manner. Clin Immunol. 2009; 131(1):170-7. DOI: 10.1016/j.clim.2008.11.005. View

17.

Trocme S, Sra K . Spectrum of ocular allergy. Curr Opin Allergy Clin Immunol. 2003; 2(5):423-7. DOI: 10.1097/00130832-200210000-00010. View

18.

Chung S, Choi S, Cho K, Joo C . Toll-like receptor 4 signalling attenuates experimental allergic conjunctivitis. Clin Exp Immunol. 2011; 164(2):275-81. PMC: 3087920. DOI: 10.1111/j.1365-2249.2011.04368.x. View

19.

Chan M, Huang H, Fenton M, Fong D . In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem Pharmacol. 1998; 55(12):1955-62. DOI: 10.1016/s0006-2952(98)00114-2. View

20.

Abe Y, Hashimoto S, Horie T . Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res. 1999; 39(1):41-7. DOI: 10.1006/phrs.1998.0404. View