An Inside View: VEGF Receptor Trafficking and Signaling

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2012 Aug 10

PMID 22875452

Citations 90

Authors

Michael Simons

Affiliations

Soon will be listed here.

Abstract

Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its function. A new layer of added complexity has been the demonstration of the importance of endocytosis and intracellular trafficking of VEGF receptors in the regulation of VEGF signaling. In this review, we consider an evolving link between VEGF receptor endocytosis, trafficking, and signaling and their biological function.

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