Understanding Implantation Window, a Crucial Phenomenon

Overview

Journal J Hum Reprod Sci

Date 2012 Aug 8

PMID 22870007

Citations 20

Authors

Alok Sharma

Pratap Kumar

Affiliations

Soon will be listed here.

Abstract

Embryo implantation is a well-defined and precise process, in which various factors come into play one after the other. There is only a specific period of time during which implantation is possible i.e. "implantation window". Selectins were proposed to have an important role in this phase to ensure suitable rolling of the blastocyst. To prevent the blastocyst from adhering to an area with poor chances of implantation, an important role is played by the repellent activity of MUC-1, which is widely expressed throughout the endometrium and, surprisingly, even increases before implantation. In particular endometrial areas, secretion of chemokines and growth factors will attract the blastocyst to landing platforms known as pinopods. These pinopods are fully developed for only 1 or 2 days and extend over the tips of the microvilli expressing the repellent MUC-1. At this stage, adhesion molecules such as integrins and cadherins intervene to ensure adhesiveness between the embryo and the endometrium.

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References

FINN C, Martin L . The control of implantation. J Reprod Fertil. 1974; 39(1):195-206. DOI: 10.1530/jrf.0.0390195. View

Pollard J, Hunt J, Wiktor-Jedrzejczak W, Stanley E . A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility. Dev Biol. 1991; 148(1):273-83. DOI: 10.1016/0012-1606(91)90336-2. View

Toda A, Piccirillo C . Development and function of naturally occurring CD4+CD25+ regulatory T cells. J Leukoc Biol. 2006; 80(3):458-70. DOI: 10.1189/jlb.0206095. View

Tabibzadeh S, Kong Q, Babaknia A, May L . Progressive rise in the expression of interleukin-6 in human endometrium during menstrual cycle is initiated during the implantation window. Hum Reprod. 1995; 10(10):2793-9. DOI: 10.1093/oxfordjournals.humrep.a135793. View

Aghajanova L, Stavreus-Evers A, Nikas Y, Hovatta O, Landgren B . Coexpression of pinopodes and leukemia inhibitory factor, as well as its receptor, in human endometrium. Fertil Steril. 2003; 79 Suppl 1:808-14. DOI: 10.1016/s0015-0282(02)04830-6. View

Lessey B, Damjanovich L, Coutifaris C, Castelbaum A, Albelda S, Buck C . Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J Clin Invest. 1992; 90(1):188-95. PMC: 443080. DOI: 10.1172/JCI115835. View

Simon C, Moreno C, Remohi J, Pellicer A . Cytokines and embryo implantation. J Reprod Immunol. 1998; 39(1-2):117-31. DOI: 10.1016/s0165-0378(98)00017-5. View

Smalley D, Ley K . L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 2005; 9(2):255-66. PMC: 6740228. DOI: 10.1111/j.1582-4934.2005.tb00354.x. View

Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z . Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 2006; 212:8-27. DOI: 10.1111/j.0105-2896.2006.00427.x. View

10.

Beagley K, Gockel C . Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone. FEMS Immunol Med Microbiol. 2003; 38(1):13-22. DOI: 10.1016/S0928-8244(03)00202-5. View

11.

Nikas G . Pinopodes as markers of endometrial receptivity in clinical practice. Hum Reprod. 2000; 14 Suppl 2:99-106. DOI: 10.1093/humrep/14.suppl_2.99. View

12.

ESPEY L . Current status of the hypothesis that mammalian ovulation is comparable to an inflammatory reaction. Biol Reprod. 1994; 50(2):233-8. DOI: 10.1095/biolreprod50.2.233. View

13.

Chaouat G, Zourbas S, Ostojic S, Lappree-Delage G, Dubanchet S, Ledee N . A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy. J Reprod Immunol. 2001; 53(1-2):241-56. DOI: 10.1016/s0165-0378(01)00119-x. View

14.

Martel D, Frydman R, Glissant M, Maggioni C, Roche D, Psychoyos A . Scanning electron microscopy of postovulatory human endometrium in spontaneous cycles and cycles stimulated by hormone treatment. J Endocrinol. 1987; 114(2):319-24. DOI: 10.1677/joe.0.1140319. View

15.

Hey N, Graham R, Seif M, Aplin J . The polymorphic epithelial mucin MUC1 in human endometrium is regulated with maximal expression in the implantation phase. J Clin Endocrinol Metab. 1994; 78(2):337-42. DOI: 10.1210/jcem.78.2.8106621. View

16.

Nilsson O . Ultrastructure of mouse uterine surface epithelium under different estrogenic influences. 3. Late effect of estrogen administered to spayed animals. J Ultrastruct Res. 1958; 2(2):185-99. DOI: 10.1016/s0022-5320(58)90017-0. View

17.

Usadi R, Murray M, Bagnell R, Fritz M, Kowalik A, Meyer W . Temporal and morphologic characteristics of pinopod expression across the secretory phase of the endometrial cycle in normally cycling women with proven fertility. Fertil Steril. 2003; 79(4):970-4. DOI: 10.1016/s0015-0282(02)04929-4. View

18.

Jasper M, Tremellen K, Robertson S . Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod. 2006; 12(5):301-8. DOI: 10.1093/molehr/gal032. View

19.

Defrere S, Van Langendonckt A, Moulin P, Befahy P, Gonzalez D, Martinez-Madrid B . Human endometrial epithelial cells (EEC) constitutively express more intercellular adhesion molecule (ICAM)-1 than endometrial stromal cells (ESC) in culture. Am J Reprod Immunol. 2005; 54(1):5-12. DOI: 10.1111/j.1600-0897.2005.00272.x. View

20.

McMaster M, Dey S, Andrews G . Association of monocytes and neutrophils with early events of blastocyst implantation in mice. J Reprod Fertil. 1993; 99(2):561-9. DOI: 10.1530/jrf.0.0990561. View