Transplantation: is Donor T-cell Engraftment a Biomarker for Tolerance?

Overview

Journal Nat Rev Nephrol

Specialty Nephrology

Date 2012 Aug 8

PMID 22868709

Citations 7

Authors

Hong Xu

Suzanne T Ildstad

Affiliations

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Citing Articles

Incidental detection of operational tolerance in a deceased donor kidney transplant recipient lost to follow-up for more than 10 years: A case report and literature review.

Roy S, Chowdhury M, Basuli D, Adapa S, Bodziak K Clin Nephrol Case Stud. 2023; 11:12-16.

PMID: 36844261 PMC: 9948746. DOI: 10.5414/CNCS111030.

TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.

Brinas F, Danger R, Brouard S Cells. 2021; 10(6).

PMID: 34206047 PMC: 8230170. DOI: 10.3390/cells10061367.

Operational tolerance in kidney transplantation and associated biomarkers.

Massart A, Ghisdal L, Abramowicz M, Abramowicz D Clin Exp Immunol. 2017; 189(2):138-157.

PMID: 28449211 PMC: 5508347. DOI: 10.1111/cei.12981.

Facilitating cells: Translation of hematopoietic chimerism to achieve clinical tolerance.

Ildstad S, Leventhal J, Wen Y, Yolcu E Chimerism. 2016; 6(1-2):33-9.

PMID: 26745761 PMC: 5063065. DOI: 10.1080/19381956.2015.1130780.

T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model.

Pilat N, Farkas A, Mahr B, Schwarz C, Unger L, Hock K J Heart Lung Transplant. 2014; 33(4):429-37.

PMID: 24468120 PMC: 3991417. DOI: 10.1016/j.healun.2013.11.004.

References

Xu H, Chilton P, Huang Y, Schanie C, Yan J, Ildstad S . Addition of cyclophosphamide to T-cell depletion-based nonmyeloablative conditioning allows donor T-cell engraftment and clonal deletion of alloreactive host T-cells after bone marrow transplantation. Transplantation. 2007; 83(7):954-63. DOI: 10.1097/01.tp.0000258679.18684.b0. View

Ozyurek E, Cowan M, Koerper M, Baxter-Lowe L, Dvorak C, Horn B . Increasing mixed chimerism and the risk of graft loss in children undergoing allogeneic hematopoietic stem cell transplantation for non-malignant disorders. Bone Marrow Transplant. 2008; 42(2):83-91. DOI: 10.1038/bmt.2008.89. View

Niederwieser D, Maris M, Shizuru J, Petersdorf E, Hegenbart U, Sandmaier B . Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can.... Blood. 2002; 101(4):1620-9. DOI: 10.1182/blood-2002-05-1340. View

Ramakrishnan S, Page A, Farris 3rd A, Singh K, Leopardi F, Hamby K . Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. Am J Transplant. 2012; 12(7):1755-64. PMC: 3387328. DOI: 10.1111/j.1600-6143.2012.04045.x. View

Leventhal J, Abecassis M, Miller J, Gallon L, Ravindra K, Tollerud D . Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med. 2012; 4(124):124ra28. PMC: 3610325. DOI: 10.1126/scitranslmed.3003509. View

Jochum C, Beste M, Zellmer E, Graves S, Storb R . CD154 blockade and donor-specific transfusions in DLA-identical marrow transplantation in dogs conditioned with 1-Gy total body irradiation. Biol Blood Marrow Transplant. 2007; 13(2):164-71. PMC: 1831459. DOI: 10.1016/j.bbmt.2006.10.031. View

Xu H, Chilton P, Huang Y, Schanie C, Ildstad S . Production of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism. J Immunol. 2004; 172(3):1463-71. DOI: 10.4049/jimmunol.172.3.1463. View

Kawai T, Cosimi A, Spitzer T, Tolkoff-Rubin N, Suthanthiran M, Saidman S . HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2008; 358(4):353-61. PMC: 2819046. DOI: 10.1056/NEJMoa071074. View

Ildstad S, Sachs D . Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature. 1984; 307(5947):168-70. DOI: 10.1038/307168a0. View

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Umemura A, Morita H, Li X, Tahan S, Monaco A, Maki T . Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation. J Immunol. 2001; 167(6):3043-8. DOI: 10.4049/jimmunol.167.6.3043. View