Pediatric Sepsis: Preparing for the Future Against a Global Scourge

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2012 Aug 7

PMID 22864953

Citations 3

Authors

Carley Riley

Rajit K Basu

Niranjan Kissoon

Derek S Wheeler

Affiliations

Soon will be listed here.

Abstract

Sepsis is a leading cause of morbidity and mortality among children worldwide. As consensus statements emerge regarding early recognition and goal-directed management of sepsis, scrutiny should be given to the unique characteristics of sepsis in children. Pediatric patients are not small adults! Sepsis epidemiology, pathophysiology, and management strategy can vary significantly from those for adults. Herein, we describe the epidemiology of pediatric sepsis, in both resource-rich and resource-poor worlds, and discuss how the pathophysiology of pediatric sepsis differs from that for adults. We discuss the timeline of management of pediatric sepsis, studying how discoveries over the past 50 years have changed the way sepsis is treated. Finally, we discuss the future of pediatric sepsis. We focus on approaches that carry the most substantive impact on the global burden of disease.

Citing Articles

Impact of restrictive versus liberal transfusion and clinical outcomes in critically ill children: A retrospective observational study.

Yuliarto S, Kadafi K, Azizah L, Susanto W, Khalasha T Health Sci Rep. 2022; 5(6):e898.

PMID: 36284935 PMC: 9584090. DOI: 10.1002/hsr2.898.

Sepsis in Pediatric Cardiac Intensive Care.

Wheeler D, Wong H Pediatr Crit Care Med. 2016; 17(8 Suppl 1):S266-71.

PMID: 27490609 PMC: 4975434. DOI: 10.1097/PCC.0000000000000796.

Kidney-lung cross-talk and acute kidney injury.

Basu R, Wheeler D Pediatr Nephrol. 2013; 28(12):2239-48.

PMID: 23334385 PMC: 5764184. DOI: 10.1007/s00467-012-2386-3.

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