A Porcine Model of Familial Adenomatous Polyposis

Overview

Journal Gastroenterology

Specialty Gastroenterology

Date 2012 Aug 7

PMID 22864254

Citations 69

Authors

Tatiana Flisikowska

Claudia Merkl

Martina Landmann

Stefan Eser

Nousin Rezaei

Xinxin Cui

Mayuko Kurome

Valeri Zakhartchenko

Barbara Kessler

Hagen Wieland

Oswald Rottmann

Roland M Schmid

Gunter Schneider

Alexander Kind

Eckhard Wolf

Dieter Saur

Angelika Schnieke

Affiliations

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Abstract

We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC(1311) mutation (orthologous to human APC(1309)) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC. This large-animal, genetic model of FAP will be useful in the development of diagnostics and therapeutics for colorectal cancer. DNA sequence data: NCBI accession number GU951771.

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