Regulation of TCR Signalling by Tyrosine Phosphatases: from Immune Homeostasis to Autoimmunity

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2012 Aug 7

PMID 22862552

Citations 43

Authors

Stephanie M Stanford

Novella Rapini

Nunzio Bottini

Affiliations

Soon will be listed here.

Abstract

More than half of the known protein tyrosine phosphatases (PTPs) in the human genome are expressed in T cells, and significant progress has been made in elucidating the biology of these enzymes in T-cell development and function. Here we provide a systematic review of the current understanding of the roles of PTPs in T-cell activation, providing insight into their mechanisms of action and regulation in T-cell receptor signalling, the phenotypes of their genetically modified mice, and their possible involvement in T-cell-mediated autoimmune disease. Our projection is that the interest in PTPs as mediators of T-cell homeostasis will continue to rise with further functional analysis of these proteins, and PTPs will be increasingly considered as targets of immunomodulatory therapies.

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