MicroRNAs in Cancer Treatment and Prognosis

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2012 Aug 4

PMID 22860232

Citations 46

Authors

Claudia Regina Gasque Schoof

Eder Leite da Silva Botelho

Alberto Izzotti

Luciana Dos Reis Vasques

Affiliations

Soon will be listed here.

Abstract

Disturbances in microRNA expression by epigenetic alterations and mutations may promote not only tumorigenesis but also tumor aggressiveness, invasion, metastasis, and resistance to chemotherapy and radiotherapy. Several studies have profiled microRNA expression in normal and tumorigenic tissues, demonstrating a unique microRNA signature, which can be used as a marker for cancer diagnosis and prognosis. This review discusses the importance of microRNAs as regulatory biomolecules involved in cancer, focusing on microRNAs related to cancer invasion, metastasis, epigenetic alterations, chemoresistance, and radioresistance. The identification of both differentially expressed microRNAs in tumors and their target genes provides new tools for gene therapy; the re-expression of microRNAs silenced by cancer development or the silencing of oncogenic microRNAs can be effective in the blockade of cancer-related cell proliferation.

Citing Articles

CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma.

Zou Q, Zhang Y, Zhu D, Liu X, Wang C, Xiang H Open Med (Wars). 2023; 18(1):20230803.

PMID: 38025527 PMC: 10655683. DOI: 10.1515/med-2023-0803.

Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs.

Thomaidou A, Batsaki P, Adamaki M, Goulielmaki M, Baxevanis C, Zoumpourlis V Int J Mol Sci. 2022; 23(15).

PMID: 35897831 PMC: 9367895. DOI: 10.3390/ijms23158257.

A Perspective of Epigenetic Regulation in Radiotherapy.

Peng Q, Weng K, Li S, Xu R, Wang Y, Wu Y Front Cell Dev Biol. 2021; 9:624312.

PMID: 33681204 PMC: 7930394. DOI: 10.3389/fcell.2021.624312.

Role of microRNA-7 in liver diseases: a comprehensive review of the mechanisms and therapeutic applications.

Han S, Zhang T, Kusumanchi P, Huda N, Jiang Y, Liangpunsakul S J Investig Med. 2020; 68(7):1208-1216.

PMID: 32843369 PMC: 9303053. DOI: 10.1136/jim-2020-001420.

Hsa_circ_0011385 accelerates the progression of thyroid cancer by targeting miR-361-3p.

Xia F, Chen Y, Jiang B, Bai N, Li X Cancer Cell Int. 2020; 20:49.

PMID: 32082079 PMC: 7017482. DOI: 10.1186/s12935-020-1120-7.

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