The -2518A/G Polymorphism in the MCP-1 Gene and Tuberculosis Risk: a Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Aug 4

PMID 22859936

Citations 13

Authors

Yonggang Zhang

Jie Zhang

Lingjun Zeng

Honglang Huang

Min Yang

Xiaowei Fu

Can Tian

Zhangpeng Xiang

Jin Huang

Hong Fan

Affiliations

Soon will be listed here.

Abstract

Background: The -2518A/G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene has been implicated in the susceptibility to tuberculosis (TB), but the results are not conclusive. The aim of this study is to investigate the association between the -2518A/G polymorphism in the MCP-1 gene and the risk of tuberculosis by meta-analysis.

Methods: We searched Pubmed, Embase, CNKI and Wanfang databases, covering all studies until April 29(th), 2011. Statistical analyses were performed using the Revman4.2 and STATA10.0 software.

Results: A total of 5341 cases and 6075 controls in 13 case-control studies were included in the meta-analysis. The results indicated that the GG homozygote carriers had a 67% increased risk of TB compared with the A allele carriers (GG vs. GA+AA: OR = 1.67, 95%CI = 1.25-2.23, P = 0.0006). In the subgroup analysis by ethnicity, significant elevated risks were found in Asians and Latinos, but not in Africans (GG vs. GA+AA: OR = 1.79, 95%CI = 1.19-2.70 and P = 0.005 for Asians; OR = 2.15, 95%CI = 1.32-3.51 and P = 0.002 for Latinos; OR = 1.28, 95%CI = 0.45-3.64 and P = 0.65 for Africans).

Conclusion: This meta-analysis suggested that the -2518A/G polymorphism of MCP-1 gene would be a risk factor for TB in Asians and Latinos, while not in Africans.

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