Intra-operative Electron Beam Radiotherapy for Newly Diagnosed and Recurrent Malignant Gliomas: Feasibility and Long-term Outcomes

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2012 Aug 3

PMID 22855176

Citations 7

Authors

Sergey Usychkin

Felipe Calvo

Marcos A Dos Santos

Jose Samblas

David Ortiz de Urbina

Jose Carlos Bustos

Jose Angel Gutierrez Diaz

Kita Sallabanda

Ana Sanz

Carmen Yelamos

Carmen Peraza

Jose Miguel Delgado

Hugo Marsiglia

Affiliations

Soon will be listed here.

Abstract

Introduction: Intra-operative electron beam radiotherapy (IOERT) is an alternative to dose escalation for the treatment of central nervous system tumors. The objective of this study was to describe the feasibility and long-term outcomes of IOERT in the treatment of primary and recurrent gliomas.

Materials And Methods: From January 1992 through December 2002, all patients treated with IOERT at the Hospital San Francisco de Asis, Madrid/Spain were retrospectively reviewed. The selection criteria included patients with superficial tumors, KPS >70 % and lesions <6 cm. Irradiation was administered in one section. The prescribed dose considered the amount of post-resection residual tumor, previous radiotherapy and the tolerance level of brain structures exposed to IOERT.

Results: There were 17 patients (53 %) with newly diagnosed malignant brain gliomas and 15 patients with recurrent tumors. The delivered dose varied from 8 to 20 Gy (median 12.5 Gy) for primary and from 8 to 16 Gy (median 10 Gy) for recurrent tumors. The median overall survival for the entire cohort was 13 months (14 and 10.4 months for the primary and recurrent, respectively). Three patients presented with radionecrosis, one patient with osteomyelitis at the craniotomy bone flap, one with intracerebral hemorrhage, and another patient experienced a pulmonary embolism.

Conclusions: IOERT is a feasible technique and can be viewed as a tool in the treatment of newly diagnosed or recurrent brain gliomas.

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