Polymorphisms in the ERCC5 Gene and Risk of Esophageal Squamous Cell Carcinoma (ESCC) in Eastern Chinese Populations

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Aug 1

PMID 22848513

Citations 19

Authors

Mei-Ling Zhu

Ting-Yan Shi

Hai-Chuan Hu

Jing He

Mengyun Wang

Li Jin

Ya-Jun Yang

Jiu-Cun Wang

Meng-Hong Sun

Huan Chen

Kuai-Le Zhao

Zhen Zhang

Hai-Quan Chen

Jia-Qing Xiang

Qing-Yi Wei

Affiliations

Soon will be listed here.

Abstract

Background: Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair; its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity and thus contribute to cancer risk.

Methodology/principal Findings: In a hospital-based case-control study of 1115 esophageal squamous cell carcinoma (ESCC) cases and 1117 cancer-free controls, we genotyped three potentially functional SNPs of ERCC5 (SNPs, rs2296147T>C, rs2094258C>T and rs873601G>A) and estimated crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for their associations with risk of ESCC using unconditional logistic regression models. We also calculated false-positive report probabilities (FPRPs) for significant findings. We found that compared with the TT genotype, ERCC5 rs2296147 C variant genotypes were associated with a significantly lower ESCC risk (CT: adjusted OR = 0.76, 95% CI = 0.63-0.93, CT/CC: adjusted OR = 0.80, 95% CI = 0.67-0.96); however, this risk was not observed for the other two SNPs (rs2094258C>T and rs873601 G>A), nor in further stratification and haplotype analysis.

Conclusions/significances: These findings suggested that ERCC5 polymorphisms may contribute to risk of ESCC in Eastern Chinese populations, but the effect was weak and needs further validation by larger population-based case-control studies.

Citing Articles

Exploring Hepatocellular Carcinoma Pathogenesis: The Influence of Genetic Polymorphisms.

Mollazadeh S, Saeedi N, Al-Asady A, Ghorbani E, Khazaei M, Ryzhikov M Curr Pharm Des. 2024; 31(6):432-442.

PMID: 39297458 DOI: 10.2174/0113816128327773240827062719.

Overview of Risk Factors for Esophageal Squamous Cell Carcinoma in China.

Conway E, Wu H, Tian L Cancers (Basel). 2023; 15(23).

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Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer.

Yang G, Yang Y, Ma X, Huang L, Li W, Song X Technol Cancer Res Treat. 2020; 19:1533033820943244.

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MassARRAY analysis of twelve cancer related SNPs in esophageal squamous cell carcinoma in J&K, India.

Shah R, Sharma V, Bhat A, Singh H, Sharma I, Verma S BMC Cancer. 2020; 20(1):497.

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RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs.

Yeo J, Morales D, Chen T, Crawford E, Zhang X, Blomquist T BMC Pulm Med. 2018; 18(1):42.

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