The Controversial Role of Sirtuins in Tumorigenesis - SIRT7 Joins the Debate

Overview

Journal Cell Res

Specialty Cell Biology

Date 2012 Aug 1

PMID 22847743

Citations 11

Authors

Ling Li

Ravi Bhatia

Affiliations

Soon will be listed here.

Abstract

Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-specific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies.

Citing Articles

USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.

Su Y, Wu C, Chang Y, Li L, Chen Y, Jia X Breast Cancer Res Treat. 2022; 196(1):31-44.

PMID: 36040642 DOI: 10.1007/s10549-022-06711-3.

Whole Blood Transcriptional Fingerprints of High-Grade Glioma and Longitudinal Tumor Evolution under Carbon Ion Radiotherapy.

Knoll M, Waltenberger M, Furkel J, Wirkner U, Ward Gahlawat A, Dokic I Cancers (Basel). 2022; 14(3).

PMID: 35158950 PMC: 8833402. DOI: 10.3390/cancers14030684.

MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels.

Sun R, Guo M, Fan X, Meng Q, Yuan D, Yang X Biomed Res Int. 2020; 2020:9568976.

PMID: 33274232 PMC: 7700026. DOI: 10.1155/2020/9568976.

Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.

Zhao Y, Ye X, Chen R, Gao Q, Zhao D, Ling C Oncol Rep. 2020; 44(3):959-972.

PMID: 32705247 PMC: 7388485. DOI: 10.3892/or.2020.7672.

Emerging Roles for SIRT5 in Metabolism and Cancer.

Bringman-Rodenbarger L, Guo A, Lyssiotis C, Lombard D Antioxid Redox Signal. 2017; 28(8):677-690.

PMID: 28707979 PMC: 5824490. DOI: 10.1089/ars.2017.7264.

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