Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients

Overview

Journal Gut Liver

Specialty Gastroenterology

Date 2012 Jul 31

PMID 22844564

Citations 6

Authors

In Soo Kim

Hyuk Lee

Jun Chul Park

Sung Kwan Shin

Sang Kil Lee

Yong Chan Lee

Affiliations

Soon will be listed here.

Abstract

Background/aims: Solid organ transplant recipients frequently report gastrointestinal symptoms, especially heartburn or dyspepsia. However, the prevalence of endoscopic erosive esophagitis (EE) and associated risk factors after transplantation are unknown. The aim of this study was to determine whether there was a high incidence of endoscopic findings of EE in solid organ transplant recipients.

Methods: This retrospective case-control study included 256 of 3,152 solid organ transplant recipients who underwent sequential screening upper endoscopic examinations and an equal number of controls.

Results: Forty-four (17.2%) and 16 (6.2%) cases of EE were detected in the solid organ transplant and control groups, respectively (p<0.001). In the multivariate analysis, transplantation was significantly associated with EE (odds ratio [OR], 6.48; 95% confidence interval, 2.74 to 15.35). Factors such as old age (OR, 1.17), the presence of a hiatal hernia (OR, 5.84), an increased duration of immunosuppression (OR, 1.07), and the maintenance administration of mycophenolate mofetil (OR, 4.13) were independently associated with the occurrence of EE in the solid organ transplant recipients.

Conclusions: A significant increase in the incidence of endoscopically detected EE was observed in solid organ transplant recipients. This increased incidence was associated with the type and duration of the immunosuppressive therapy.

Citing Articles

Risk of esophageal cancer in liver transplant recipients: systematic review and meta-analysis.

Li S, Zhang S, Sun X J Gastrointest Oncol. 2024; 15(3):851-861.

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Neoplastic Progression of Barrett's Esophagus Among Organ Transplant Recipients: a Retrospective Cohort Study.

Patel V, Sanaka M, Qin Y, McMichael J, Bena J, Beveridge C J Gastrointest Surg. 2023; 27(9):1785-1793.

PMID: 37268829 DOI: 10.1007/s11605-023-05722-9.

Nausea, Vomiting, and Dyspepsia Following Solid Organ Abdominal Transplant.

Jarrett S, Lo K, Body C, Kim J, Zheng Z, Kundu S Cureus. 2022; 14(4):e24274.

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Recalcitrant Esophageal Stricture Secondary to Mycophenolate Mofetil.

Kim J, Mulki R, Sebastian K Case Rep Gastrointest Med. 2020; 2020:8817801.

PMID: 33299620 PMC: 7704200. DOI: 10.1155/2020/8817801.

Histologic diagnosis and grading of esophageal acute graft-versus-host disease.

Kreft A, Neumann H, von Bach D, Wagner-Drouet E Virchows Arch. 2019; 474(3):325-332.

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