Subcutaneous Administration of RhIGF-I Post Irradiation Exposure Enhances Hematopoietic Recovery and Survival in BALB/c Mice

Overview

Journal J Radiat Res

Publisher Oxford University Press

Specialties Environmental Health
Oncology
Radiology

Date 2012 Jul 31

PMID 22843623

Citations 4

Authors

Shilei Chen

Yang Xu

Song Wang

Mingqiang Shen

Fang Chen

Mo Chen

Aiping Wang

Tianmin Cheng

Yongping Su

Junping Wang

Affiliations

Soon will be listed here.

Abstract

It is unclear how to effectively mitigate against irradiation injury. In this study, we studied the capacity of recombinant human insulin-like growth factor-I (rhIGF-I) on hematologic recovery in irradiated BALB/c mice and its possible mechanism. BALB/c mice were injected with rhIGF-I subcutaneously at a dose of 100 μg/kg twice daily for 7 days after total body irradiation. Compared with a saline control group, treatment with rhIGF-I significantly improved the survival of mice after lethal irradiation (7.5 Gy). It was found that treatment with rhIGF-I not only could increase the frequency of Sca-1(+) cells in bone marrow harvested at Day 14 after irradiation, but also it could decrease the apoptosis of mononuclear cells induced by irradiation as measured by flow cytometry, suggesting that rhIGF-I may mediate its effects primarily through promoting hematopoietic stem cell/progenitor survival and protecting mononuclear cells from apoptosis after irradiation exposure. Moreover, we have found that rhIGF-I might facilitate thrombopoiesis in an indirect way. Our data demonstrated that rhIGF-I could promote overall hematopoietic recovery after ionizing radiation and reduce the mortality when administered immediately post lethal irradiation exposure.

Citing Articles

Mitigation of Ionizing Radiation-Induced Gastrointestinal Damage by Insulin-Like Growth Factor-1 in Mice.

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Insulin-like growth factor-1 short-period therapy stimulates bone marrow cells in obese swiss mice.

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Alterations in the corneal nerve and stem/progenitor cells in diabetes: preventive effects of insulin-like growth factor-1 treatment.

Ueno H, Hattori T, Kumagai Y, Suzuki N, Ueno S, Takagi H Int J Endocrinol. 2014; 2014:312401.

PMID: 24696681 PMC: 3948593. DOI: 10.1155/2014/312401.

Simvastatin attenuates radiation-induced tissue damage in mice.

Zhao X, Yang H, Jiang G, Ni M, Deng Y, Cai J J Radiat Res. 2013; 55(2):257-64.

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