Animal Models for Medications Development Targeting Alcohol Abuse Using Selectively Bred Rat Lines: Neurobiological and Pharmacological Validity

Overview

Journal Pharmacol Biochem Behav

Publisher Elsevier

Specialties Biochemistry
Pharmacology
Psychology
Social Sciences

Date 2012 Jul 31

PMID 22841890

Citations 70

Authors

Richard L Bell

Helen J K Sable

Giancarlo Colombo

Petri Hyytia

Zachary A Rodd

Lawrence Lumeng

Affiliations

Soon will be listed here.

Abstract

The purpose of this review paper is to present evidence that rat animal models of alcoholism provide an ideal platform for developing and screening medications that target alcohol abuse and dependence. The focus is on the 5 oldest international rat lines that have been selectively bred for a high alcohol-consumption phenotype. The behavioral and neurochemical phenotypes of these rat lines are reviewed and placed in the context of the clinical literature. The paper presents behavioral models for assessing the efficacy of pharmaceuticals for the treatment of alcohol abuse and dependence in rodents, with particular emphasis on rats. Drugs that have been tested for their effectiveness in reducing alcohol/ethanol consumption and/or self-administration by these rat lines and their putative site of action are summarized. The paper also presents some current and future directions for developing pharmacological treatments targeting alcohol abuse and dependence.

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