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Congenital Hypothyroidism Caused by Excess Prenatal Maternal Iodine ingestion

Overview
Journal J Pediatr
Specialty Pediatrics
Date 2012 Jul 31
PMID 22841183
Citations 47
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Abstract

We report the cases of 3 infants with congenital hypothyroidism detected with the use of our newborn screening program, with evidence supporting excess maternal iodine ingestion (12.5 mg/d) as the etiology. Levels of whole blood iodine extracted from their newborn screening specimens were 10 times above mean control levels. Excess iodine ingestion from nutritional supplements is often unrecognized.

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References
1.
Stagi S, Manoni C, Chiarelli F, de Martino M . Congenital hypothyroidism due to unexpected iodine sources. Horm Res Paediatr. 2010; 74(1):76. DOI: 10.1159/000295697. View

2.
Rhee S, Braverman L, Pino S, He X, Pearce E . High iodine content of Korean seaweed soup: a health risk for lactating women and their infants?. Thyroid. 2011; 21(8):927-8. DOI: 10.1089/thy.2011.0084. View

3.
Leung A, Pearce E, Hamilton T, He X, Pino S, Merewood A . Colostrum iodine and perchlorate concentrations in Boston-area women: a cross-sectional study. Clin Endocrinol (Oxf). 2008; 70(2):326-30. DOI: 10.1111/j.1365-2265.2008.03330.x. View

4.
Thomas J, Collett-Solberg P . Perinatal goiter with increased iodine uptake and hypothyroidism due to excess maternal iodine ingestion. Horm Res. 2009; 72(6):344-7. DOI: 10.1159/000249162. View

5.
Markou K, GEORGOPOULOS N, Kyriazopoulou V, Vagenakis A . Iodine-Induced hypothyroidism. Thyroid. 2001; 11(5):501-10. DOI: 10.1089/105072501300176462. View