Neural Circuitry Engaged by Prostaglandins During the Sickness Syndrome

Overview

Journal Nat Neurosci

Date 2012 Jul 28

PMID 22837039

Citations 123

Authors

Clifford B Saper

Andrej A Romanovsky

Thomas E Scammell

Affiliations

Soon will be listed here.

Abstract

During illnesses caused by infectious disease or other sources of inflammation, a suite of brain-mediated responses called the sickness syndrome occurs, which includes fever, anorexia, sleepiness, hyperalgesia and elevated corticosteroid secretion. Much of the sickness syndrome is mediated by prostaglandins acting on the brain and can be prevented by nonsteroidal anti-inflammatory drugs, such as aspirin or ibuprofen, that block prostaglandin synthesis. By examining which prostaglandins are produced at which sites and how they interact with the nervous system, researchers have identified specific neural circuits that underlie the sickness syndrome.

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