Effects of Two Neuroleptic Drugs on Focal Somatoparietal Rhythms in Free Awake Cats

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1979 Sep 1

PMID 228337

Citations 2

Authors

J J Bouyer

J P Joseph

A ROUGEUL

Affiliations

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Abstract

In freely moving cats, systemic administration of Chlorpromazine (CPZ) and Haloperidol (HP), two neuroleptics which presumably block catecholamine receptors, leads to a suppression of the waking mu-type rhythms. There is a clear difference, however, in that CPZ leads to slow wave sleep while HP only induces sustained drowsiness. The difference in their action is tentatively explained by their differential effect on an enzyme that is not involved in the metabolism of biogenic amines, tryptophan pyrrolase. We suggest that it is through this pathway that CPZ might increase and HP might decrease brain tryptophan and thereby lead to opposite changes in brain 5-HT content.

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