Emerging Tools for Erectile Dysfunction: a Role for Regenerative Medicine

Overview

Journal Nat Rev Urol

Specialty Urology

Date 2012 Jul 25

PMID 22824778

Citations 11

Authors

Lukman Hakim

Frank Van der Aa

Trinity J Bivalacqua

Petter Hedlund

Maarten Albersen

Affiliations

Soon will be listed here.

Abstract

Erectile dysfunction (ED) is the most common sexual disorder reported by men to their health-care providers and the most investigated male sexual dysfunction. Currently, the treatment of ED focuses on 'symptomatic relief' of ED and, therefore, tends to provide temporary relief rather than providing a cure or reversing the cause. The identification of a large population of "difficult-to-treat" patients has triggered researchers to identify novel treatment approaches, which focus on cure and restoration of the underlying cause of ED. Regenerative medicine has developed extensively in the past few decades and preclinical trials have emphasized the benefit of growth factor therapy, gene transfer, stem cells and tissue engineering for the restoration of erectile function. Development of clinical trials involving immunomodulation in postprostatectomy ED patients and the use of maxi-K channels for gene therapy are illustrative of the advances in the field. However, the search for novel treatment targets and a wealth of preclinical studies represent a dynamic and continuing field of enquiry.

Citing Articles

A potential treatment for erectile dysfunction: Effect of platelet-rich plasma administration on axon and collagen regeneration in cavernous nerve injury.

Ismy J, Khalilullah S, Maulana R, Hidayatullah F Narra J. 2024; 4(2):e880.

PMID: 39280316 PMC: 11391956. DOI: 10.52225/narra.v4i2.880.

NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.

Luo C, Peng Y, Zhou X, Fan J, Chen W, Zhang H Front Endocrinol (Lausanne). 2022; 13:913296.

PMID: 35937790 PMC: 9354456. DOI: 10.3389/fendo.2022.913296.

Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA).

Liu J, Chu K, Gabrielson A, Wang R, Trost L, Broderick G Sex Med. 2021; 9(3):100343.

PMID: 34000480 PMC: 8240368. DOI: 10.1016/j.esxm.2021.100343.

Intracavernous Injection of Autologous Platelet-Rich Plasma Ameliorates Hyperlipidemia-Associated Erectile Dysfunction in a Rat Model.

Huang Y, Wu C, Chen M, Kuo Y, Li J, Shi C Sex Med. 2021; 9(2):100317.

PMID: 33529811 PMC: 8072173. DOI: 10.1016/j.esxm.2020.100317.

Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury.

Campbell J, Burnett A Int J Mol Sci. 2017; 18(8).

PMID: 28820434 PMC: 5578182. DOI: 10.3390/ijms18081794.

References

Melman A, Bar-Chama N, McCullough A, Davies K, Christ G . The first human trial for gene transfer therapy for the treatment of erectile dysfunction: preliminary results. Eur Urol. 2005; 48(2):314-8. DOI: 10.1016/j.eururo.2005.05.005. View

So I, Chae M, Lee S . Gene transfer of the K(ATP) channel restores age-related erectile dysfunction in rats. BJU Int. 2007; 100(5):1154-60. DOI: 10.1111/j.1464-410X.2007.07050.x. View

Abdel Aziz M, El-Haggar S, Mostafa T, Atta H, Fouad H, Mahfouz S . Effect of mesenchymal stem cell penile transplantation on erectile signaling of aged rats. Andrologia. 2010; 42(3):187-92. DOI: 10.1111/j.1439-0272.2009.00977.x. View

Harraz A, Shindel A, Lue T . Emerging gene and stem cell therapies for the treatment of erectile dysfunction. Nat Rev Urol. 2010; 7(3):143-52. PMC: 3927494. DOI: 10.1038/nrurol.2010.8. View

Qiu X, Lin H, Wang Y, Yu W, Chen Y, Wang R . Intracavernous transplantation of bone marrow-derived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats. J Sex Med. 2010; 8(2):427-36. DOI: 10.1111/j.1743-6109.2010.02118.x. View

Bivalacqua T, Burnett A, Hellstrom W, Champion H . Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase. Am J Physiol Heart Circ Physiol. 2006; 292(3):H1340-51. DOI: 10.1152/ajpheart.00121.2005. View

Bella A, Lin G, Tantiwongse K, Garcia M, Lin C, Brant W . Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: part I. J Sex Med. 2006; 3(5):815-820. DOI: 10.1111/j.1743-6109.2006.00291.x. View

Abdelbaky T, Brock G, Huynh H . Improvement of erectile function in diabetic rats by insulin: possible role of the insulin-like growth factor system. Endocrinology. 1998; 139(7):3143-7. DOI: 10.1210/endo.139.7.6120. View

Pu X, Hu L, Wang H, Luo Y, Wang X . Improvement in erectile dysfunction after insulin-like growth factor-1 gene therapy in diabetic rats. Asian J Androl. 2006; 9(1):83-91. DOI: 10.1111/j.1745-7262.2007.00215.x. View

10.

Saigal C, Wessells H, Pace J, Schonlau M, Wilt T . Predictors and prevalence of erectile dysfunction in a racially diverse population. Arch Intern Med. 2006; 166(2):207-12. DOI: 10.1001/archinte.166.2.207. View

11.

Lin G, Qiu X, Fandel T, Banie L, Wang G, Lue T . Tracking intracavernously injected adipose-derived stem cells to bone marrow. Int J Impot Res. 2011; 23(6):268-75. PMC: 3516363. DOI: 10.1038/ijir.2011.38. View

12.

Lin G, Bella A, Lue T, Lin C . Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: part 2. J Sex Med. 2006; 3(5):821-829. DOI: 10.1111/j.1743-6109.2006.00292.x. View

13.

Burnett A . Erectile dysfunction management for the future. J Androl. 2008; 30(4):391-6. DOI: 10.2164/jandrol.108.006106. View

14.

Champion H, Bivalacqua T, HYMAN A, Ignarro L, Hellstrom W, Kadowitz P . Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proc Natl Acad Sci U S A. 1999; 96(20):11648-52. PMC: 18088. DOI: 10.1073/pnas.96.20.11648. View

15.

Albersen M, Shindel A, Mwamukonda K, Lue T . The future is today: emerging drugs for the treatment of erectile dysfunction. Expert Opin Emerg Drugs. 2010; 15(3):467-80. PMC: 3163612. DOI: 10.1517/14728214.2010.480973. View

16.

Bella A, Fandel T, Tantiwongse K, Brant W, Klein R, Garcia C . Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat. J Brachial Plex Peripher Nerve Inj. 2007; 2:5. PMC: 1820781. DOI: 10.1186/1749-7221-2-5. View

17.

Derogatis L, Burnett A . The epidemiology of sexual dysfunctions. J Sex Med. 2007; 5(2):289-300. DOI: 10.1111/j.1743-6109.2007.00668.x. View

18.

Hatzimouratidis K . Editorial comment on: Smooth-muscle-specific gene transfer with the human maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys. Eur Urol. 2009; 56(6):1066. DOI: 10.1016/j.eururo.2008.12.017. View

19.

Shen Z, Wang H, Lu Y, Zhou X, Chen S, Chen Z . Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat. BJU Int. 2005; 95(6):890-4. DOI: 10.1111/j.1464-410X.2005.05422.x. View

20.

Matsuura S, Obara T, Tsuchiya N, Suzuki Y, Habuchi T . Cavernous nerve regeneration by biodegradable alginate gel sponge sheet placement without sutures. Urology. 2006; 68(6):1366-71. DOI: 10.1016/j.urology.2006.09.051. View