Myeloid-derived Suppressor Cells: Mechanisms of Action and Recent Advances in Their Role in Transplant Tolerance

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2012 Jul 24

PMID 22822406

Citations 42

Authors

Nahzli Dilek

Romain Vuillefroy de Silly

Gilles Blancho

Bernard Vanhove

Affiliations

Soon will be listed here.

Abstract

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses in infection, chronic inflammation, cancer, and autoimmunity. In this paper, we review recent findings detailing their mode of action and discuss recent reports that suggest that MDSC are also expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection as well as graft-versus-host disease.

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